DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer

Genetic aberrations in DNA repair genes are linked to cancer, but less is reported about epigenetic regulation of DNA repair and functional consequences. We investigated the intragenic methylation loss at the three prime repair exonuclease 2 (TREX2) locus in laryngeal (n = 256) and colorectal cancer...

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Main Authors:	Weigel, Christoph (Author) , Assenov, Yassen (Author) , Winkler, Volker (Author) , Santi, Irene (Author) , Kaucher, Simone (Author) , Lorenzo Bermejo, Justo (Author) , Lasitschka, Felix (Author) , Herold-Mende, Christel (Author) , Dyckhoff, Gerhard (Author) , Boukamp, Petra (Author) , Plass, Christoph (Author) , Becher, Heiko (Author) , Schmezer, Peter (Author) , Ramroth, Heribert (Author) , Popanda, Odilia (Author)
Format:	Article (Journal)
Language:	English
Published:	03 May 2019
In:	Clinical epigenetics Year: 2019, Volume: 11, Issue: 1
ISSN:	1868-7083
DOI:	10.1186/s13148-019-0666-5
Online Access:	Verlag, Volltext: https://doi.org/10.1186/s13148-019-0666-5
Author Notes:	Christoph Weigel, Jittiporn Chaisaingmongkol, Yassen Assenov, Christine Kuhmann, Volker Winkler, Irene Santi, Olga Bogatyrova, Simone Kaucher, Justo L. Bermejo, Suet Y. Leung, Tsun L. Chan, Felix Lasitschka, Manfred H. Bohrer, Alexander Marx, Roland Heyny-von Haußen, Christel Herold-Mende, Gerhard Dyckhoff, Petra Boukamp, Klaus W. Delank, Karl Hörmann, Burkhard M. Lippert, Gerald Baier, Andreas Dietz, Christopher C. Oakes, Christoph Plass, Heiko Becher, Peter Schmezer, Heribert Ramroth and Odilia Popanda