Pleiotropic effect of lipoprotein-apheresis on the soluble form of activated leukocyte Cell adhesion molecule (sALCAM) in familial hypercholesterolaemia
Atherosclerosis is an inflammatory disorder in which several converging immune responses modulate and induce lipid accumulation in macrophages. Activated leukocyte cell adhesion molecule (ALCAM) has been described as a structural homologue of HDL-receptor and functions as a pattern recognition recep...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2019
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| In: |
Experimental and clinical endocrinology & diabetes
Year: 2018, Volume: 127, Issue: 5, Pages: 276-280 |
| ISSN: | 1439-3646 |
| DOI: | 10.1055/a-0630-0232 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1055/a-0630-0232 Verlag, lizenzpflichtig, Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/a-0630-0232 
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| Author Notes: | Rüdiger von Bauer, Dimitrios Oikonomou, Alba Sulaj, Stefan Kopf, Thomas Fleming, Gottfried Rudofsky, Peter Nawroth |
| Summary: | Atherosclerosis is an inflammatory disorder in which several converging immune responses modulate and induce lipid accumulation in macrophages. Activated leukocyte cell adhesion molecule (ALCAM) has been described as a structural homologue of HDL-receptor and functions as a pattern recognition receptor (PRR), while its soluble form sALCAM is involved in ALCAM-dependent and -independent immune mechanisms. The aim of this study was to investigate the effect of aggressive removal of low density lipoprotein-cholesterol (LDL-C) and lipoprotein(a) (Lp [a]) by lipoprotein-apheresis (LA) on sALCAM and blood viscosity as well as to evaluate its association with lipoproteins and serum markers of inflammation.</p> |
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| Item Description: | Publikationsdatum: 11. Juni 2018 Gesehen am 25.06.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1439-3646 |
| DOI: | 10.1055/a-0630-0232 |