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NHC-gold compounds mediate immune suppression through induction of AHR-TGFβ1 signalling in vitro and in scurfy mice

Cheng, Haeberle et al. identify NHC-gold complexes as ligands of the aryl hydrocarbon receptor, which triggers TGFβ production for immune suppression. They find that the MC3 compound activates TGFβ signalling while reducing Il-2 expression and CD4+ T-cell activation and suppresses autoimmune phenoty...

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Main Authors: Cheng, Xinlai (Author) , Häberle, Stefanie (Author) , Shytaj, Iart Luca (Author) , Ghafoory, Shahrouz (Author) , Bauer, Andrea (Author) , Hoheisel, Jörg D. (Author) , Fackler, Oliver Till (Author) , Lusic, Marina (Author) , Hadaschik, Eva (Author) , Wölfl, Stefan (Author)
Format: Article (Journal)
Language:English
Published: 03 January 2020
In: Communications biology
Year: 2020, Volume: 3
ISSN:2399-3642
DOI:10.1038/s42003-019-0716-8
Online Access:Verlag, Volltext: https://doi.org/10.1038/s42003-019-0716-8
Verlag: https://www.nature.com/articles/s42003-019-0716-8
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Author Notes:Xinlai Cheng, Stefanie Haeberle, Iart Luca Shytaj, Rodrigo A. Gama-Brambila, Jannick Theobald, Shahrouz Ghafoory, Jessica Wölker, Uttara Basu, Claudia Schmidt, Annika Timm, Katerina Taškova, Andrea S. Bauer, Jörg Hoheisel, Nikolaos Tsopoulidis, Oliver T. Fackler, Andrea Savarino, Miguel A. Andrade-Navarro, Ingo Ott, Marina Lusic, Eva N. Hadaschik & Stefan Wölfl
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Summary:Cheng, Haeberle et al. identify NHC-gold complexes as ligands of the aryl hydrocarbon receptor, which triggers TGFβ production for immune suppression. They find that the MC3 compound activates TGFβ signalling while reducing Il-2 expression and CD4+ T-cell activation and suppresses autoimmune phenotypes in a mouse model of IPEX syndrome.
Item Description:Gesehen am 10.03.2020
Physical Description:Online Resource
ISSN:2399-3642
DOI:10.1038/s42003-019-0716-8

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