NHC-gold compounds mediate immune suppression through induction of AHR-TGFβ1 signalling in vitro and in scurfy mice
Cheng, Haeberle et al. identify NHC-gold complexes as ligands of the aryl hydrocarbon receptor, which triggers TGFβ production for immune suppression. They find that the MC3 compound activates TGFβ signalling while reducing Il-2 expression and CD4+ T-cell activation and suppresses autoimmune phenoty...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
03 January 2020
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| In: |
Communications biology
Year: 2020, Jahrgang: 3 |
| ISSN: | 2399-3642 |
| DOI: | 10.1038/s42003-019-0716-8 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1038/s42003-019-0716-8 Verlag: https://www.nature.com/articles/s42003-019-0716-8 
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| Verfasserangaben: | Xinlai Cheng, Stefanie Haeberle, Iart Luca Shytaj, Rodrigo A. Gama-Brambila, Jannick Theobald, Shahrouz Ghafoory, Jessica Wölker, Uttara Basu, Claudia Schmidt, Annika Timm, Katerina Taškova, Andrea S. Bauer, Jörg Hoheisel, Nikolaos Tsopoulidis, Oliver T. Fackler, Andrea Savarino, Miguel A. Andrade-Navarro, Ingo Ott, Marina Lusic, Eva N. Hadaschik & Stefan Wölfl |
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