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Association of graft effluent parameters with donor body mass index, graft quality, and post-transplant events

[b]BACKGROUND[/b] - We evaluated whether effluent parameters prior to reperfusion correlate with post-transplant outcomes in liver transplant recipients. - [b]MATERIAL AND METHODS[/b] - Concentrations of high mobility group box 1 protein (HMGB1), uncleaved cytokeratin-18 (M65), caspase-cleaved cytok...

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Hauptverfasser: Oweira, Hani (VerfasserIn) , Lahdou, Imad (VerfasserIn) , Daniel, Volker (VerfasserIn) , Schmidt, Jan (VerfasserIn) , Mehrabi, Arianeb (VerfasserIn) , Sadeghi, Mahmoud (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2018.02.23
In: Annals of transplantation
Year: 2018, Jahrgang: 23, Pages: 136-143
ISSN:1425-9524
DOI:10.12659/AOT.906028
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.12659/AOT.906028
Verlag, lizenzpflichtig, Volltext: https://www.annalsoftransplantation.com/abstract/index/idArt/906028
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Verfasserangaben:Hani Oweira, Imad Lahdou, Volker Daniel, Jan Schmidt, Arianeb Mehrabi, Mahmoud Sadeghi
Beschreibung
Zusammenfassung:[b]BACKGROUND[/b] - We evaluated whether effluent parameters prior to reperfusion correlate with post-transplant outcomes in liver transplant recipients. - [b]MATERIAL AND METHODS[/b] - Concentrations of high mobility group box 1 protein (HMGB1), uncleaved cytokeratin-18 (M65), caspase-cleaved cytokeratin 18 fragment (M30), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), and alkaline phosphatase (ALP) were measured in effluent samples from 53 adult liver recipients (42 survived for 1 year and 11 did not survive). - [b]RESULTS[/b] - Effluent concentrations of ALP (p=0.006), AST (p=0.050), and Ca++ (p=0.003) were higher in patients with bacteriemia in the first post-transplant year and ALP (p=0.015) was higher in patients with early graft dysfunction (EAD). Multivariate analysis of effluent parameters showed that Ca++ >0.30 mmol/l (p=0.012, odds ratio [OR]=7.12, confidence interval [CI]=1.56-32.58), and ALP ≥27 IU/l (p=0.033, OR=5.31, CI=1.14-27.74) were significantly associated with 1-year post-transplant bacteriemia, whereas ALP ≥27 IU/l (p=0.020, OR=5.56, CI=1.32-23.46) was significantly associated with EAD. HMGB1 >54 pg/ml (p=0.008, OR=6.05, CI=1.59-23.00) was significantly associated with the donor body mass index (p=0.008, OR=6.05, CI=1.59-23.00) and fatty liver (p=0.005, OR=11.68, CI=2.10-64.01). - [b]CONCLUSIONS[/b] - Effluent parameters are indicators of liver quality and predict the outcome of liver transplantation. High effluent Ca++ and ALP are risk factors of post-transplant bacteriemia. In addition, high ALP is a risk factor of EAD, and high HMGB1 is an indicator of liver quality.
Beschreibung:Gesehen am 11.03.2020
Beschreibung:Online Resource
ISSN:1425-9524
DOI:10.12659/AOT.906028

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