Dynamics of particle uptake at cell membranes
Receptor-mediated endocytosis requires that the energy of adhesion overcomes the deformation energy of the plasma membrane. The resulting driving force is balanced by dissipative forces, leading to deterministic dynamical equations. While the shape of the free membrane does not play an important rol...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
14 November 2019
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| In: |
Physical review
Year: 2019, Volume: 100, Issue: 5 |
| ISSN: | 2470-0053 |
| DOI: | 10.1103/PhysRevE.100.052403 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1103/PhysRevE.100.052403 Verlag, lizenzpflichtig, Volltext: https://link.aps.org/doi/10.1103/PhysRevE.100.052403 
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| Author Notes: | Felix Frey, Falko Ziebert, and Ulrich S. Schwarz |
| Summary: | Receptor-mediated endocytosis requires that the energy of adhesion overcomes the deformation energy of the plasma membrane. The resulting driving force is balanced by dissipative forces, leading to deterministic dynamical equations. While the shape of the free membrane does not play an important role for tensed and loose membranes, in the intermediate regime it leads to an important energy barrier. Here we show that this barrier is similar to but different from an effective line tension and suggest a simple analytical approximation for it. We then explore the rich dynamics of uptake for particles of different shapes and present the corresponding dynamical state diagrams. We also extend our model to include stochastic fluctuations, which facilitate uptake and lead to corresponding changes in the phase diagrams. |
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| Item Description: | Gesehen am 11.03.2020 |
| Physical Description: | Online Resource |
| ISSN: | 2470-0053 |
| DOI: | 10.1103/PhysRevE.100.052403 |