DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia
Christoph Plass, Christopher Oakes and colleagues study genome-wide DNA methylation dynamics during B cell maturation and the pathogenic role of transcription factor dysregulation in chronic lymphocytic leukemia (CLL). By comparing normal and malignant B cells, they find that tumors derive from a co...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
18 January 2016
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| In: |
Nature genetics
Year: 2016, Volume: 48, Issue: 3, Pages: 253-264 |
| ISSN: | 1546-1718 |
| DOI: | 10.1038/ng.3488 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/ng.3488 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/ng.3488 
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| Author Notes: | Christopher C. Oakes, Marc Seifert, Yassen Assenov, Lei Gu, Martina Przekopowitz, Amy S. Ruppert, Qi Wang, Charles D. Imbusch, Andrius Serva, Sandra D. Koser, David Brocks, Daniel B. Lipka, Olga Bogatyrova, Dieter Weichenhan, Benedikt Brors, Laura Rassenti, Thomas J. Kipps, Daniel Mertens, Marc Zapatka, Peter Lichter, Hartmut Döhner, Ralf Küppers, Thorsten Zenz, Stephan Stilgenbauer, John C. Byrd & Christoph Plass |
| Summary: | Christoph Plass, Christopher Oakes and colleagues study genome-wide DNA methylation dynamics during B cell maturation and the pathogenic role of transcription factor dysregulation in chronic lymphocytic leukemia (CLL). By comparing normal and malignant B cells, they find that tumors derive from a continuum of maturation states, which correlate with different clinical outcomes. |
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| Item Description: | Gesehen am 13.03.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1546-1718 |
| DOI: | 10.1038/ng.3488 |