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Evidence-based recommendations for blinding in surgical trials

Blinding reduces performance and detection bias in randomized controlled trials (RCT). There is evidence that lack of blinding leads to overestimation of treatment effects in pharmacological trials. Since surgical trials use interventions with a physical component, blinding is often complicated. The...

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Bibliographic Details
Main Authors: Probst, Pascal (Author) , Zaschke, Steffen (Author) , Heger, Patrick (Author) , Harnoß, Julian-Camill (Author) , Hüttner, Felix (Author) , Mihaljevic, André Leopold (Author) , Knebel, Phillip (Author) , Diener, Markus K. (Author)
Format: Article (Journal)
Language:English
Published: 1 March 2019
In: Langenbeck's archives of surgery
Year: 2019, Volume: 404, Issue: 3, Pages: 273-284
ISSN:1435-2451
DOI:10.1007/s00423-019-01761-6
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00423-019-01761-6
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Author Notes:Pascal Probst, Steffen Zaschke, Patrick Heger, Julian C. Harnoss, Felix J. Hüttner, André L. Mihaljevic, Phillip Knebel, Markus K. Diener
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Summary:Blinding reduces performance and detection bias in randomized controlled trials (RCT). There is evidence that lack of blinding leads to overestimation of treatment effects in pharmacological trials. Since surgical trials use interventions with a physical component, blinding is often complicated. The aim of this study was to analyze, in general and abdominal surgery RCT, the status of blinding, the potential for blinding, and the influence of blinding on outcomes.
Item Description:Gesehen am 27.03.2020
Physical Description:Online Resource
ISSN:1435-2451
DOI:10.1007/s00423-019-01761-6

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