Evidence-based recommendations for blinding in surgical trials
Blinding reduces performance and detection bias in randomized controlled trials (RCT). There is evidence that lack of blinding leads to overestimation of treatment effects in pharmacological trials. Since surgical trials use interventions with a physical component, blinding is often complicated. The...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1 March 2019
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| In: |
Langenbeck's archives of surgery
Year: 2019, Jahrgang: 404, Heft: 3, Pages: 273-284 |
| ISSN: | 1435-2451 |
| DOI: | 10.1007/s00423-019-01761-6 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00423-019-01761-6 |
| Verfasserangaben: | Pascal Probst, Steffen Zaschke, Patrick Heger, Julian C. Harnoss, Felix J. Hüttner, André L. Mihaljevic, Phillip Knebel, Markus K. Diener |
MARC
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| 520 | |a Blinding reduces performance and detection bias in randomized controlled trials (RCT). There is evidence that lack of blinding leads to overestimation of treatment effects in pharmacological trials. Since surgical trials use interventions with a physical component, blinding is often complicated. The aim of this study was to analyze, in general and abdominal surgery RCT, the status of blinding, the potential for blinding, and the influence of blinding on outcomes. | ||
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