Outcome after neoadjuvant chemotherapy in estrogen receptor-positive and progesterone receptor-negative breast cancer patients: a pooled analysis of individual patient data from ten prospectively randomized controlled neoadjuvant trials

The estrogen receptor (ER) is involved in control of progesterone receptor (PgR) expression and lack of PgR may be also a surrogate of altered growth factor signaling. The aim of this study was therefore to investigate PgR expression as predictive factor for response to neoadjuvant therapy and long-...

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Main Authors: Mackelenbergh, Marion Tina van (Author) , Denkert, Carsten (Author) , Nekljudova, Valentina (Author) , Karn, Thomas (Author) , Schem, Christian (Author) , Marmé, Frederik (Author) , Stickeler, Elmar (Author) , Jackisch, Christian (Author) , Hanusch, Claus (Author) , Huober, Jens (Author) , Fasching, Peter A. (Author) , Blohmer, Jens-Uwe (Author) , Kümmel, Sherko (Author) , Müller, Volkmar (Author) , Schneeweiss, Andreas (Author) , Untch, Michael (Author) , Minckwitz, Gunter von (Author) , Weber, Karsten E. (Author) , Loibl, Sibylle (Author)
Format: Article (Journal)
Language:English
Published: 2018
In: Breast cancer research and treatment
Year: 2018, Volume: 167, Issue: 1, Pages: 59-71
ISSN:1573-7217
DOI:10.1007/s10549-017-4480-5
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s10549-017-4480-5
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Author Notes:Marion T. van Mackelenbergh, Carsten Denkert, Valentina Nekljudova, Thomas Karn, Christian Schem, Frederik Marmé, Elmar Stickeler, Christian Jackisch, Claus Hanusch, Jens Huober, Peter A. Fasching, Jens-Uwe Blohmer, Sherko Kümmel, Volkmar Müller, Andreas Schneeweiss, Michael Untch, Gunter von Minckwitz, Karsten E. Weber, Sibylle Loibl
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Summary:The estrogen receptor (ER) is involved in control of progesterone receptor (PgR) expression and lack of PgR may be also a surrogate of altered growth factor signaling. The aim of this study was therefore to investigate PgR expression as predictive factor for response to neoadjuvant therapy and long-term outcome.
Item Description:Gesehen am 19.03.2020
Published online: 5 September 2017
Physical Description:Online Resource
ISSN:1573-7217
DOI:10.1007/s10549-017-4480-5