Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond
Imbalances in the kynurenine pathway (KP) of tryptophan metabolism are associated with CNS disorders, infectious diseases, autoimmune diseases and cancer, highlighting KP enzymes as potential therapeutic targets. Here, Platten and colleagues provide an overview of the physiological and pathophysiolo...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
13 February 2019
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| In: |
Nature reviews. Drug discovery
Year: 2019, Volume: 18, Issue: 5, Pages: 379-401 |
| ISSN: | 1474-1784 |
| DOI: | 10.1038/s41573-019-0016-5 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41573-019-0016-5 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41573-019-0016-5 
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| Author Notes: | Michael Platten, Ellen A.A. Nollen, Ute F. Röhrig, Francesca Fallarino and Christiane A. Opitz |
| Summary: | Imbalances in the kynurenine pathway (KP) of tryptophan metabolism are associated with CNS disorders, infectious diseases, autoimmune diseases and cancer, highlighting KP enzymes as potential therapeutic targets. Here, Platten and colleagues provide an overview of the physiological and pathophysiological roles of tryptophan metabolism, focusing on the clinical potential and challenges associated with targeting this pathway. |
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| Item Description: | Gesehen am 26.03.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1474-1784 |
| DOI: | 10.1038/s41573-019-0016-5 |