Buchumschlag

The impact of positive resection margins on survival and recurrence following resection and adjuvant chemotherapy for pancreatic ductal adenocarcinoma

Objective and Background: Local and distant disease recurrence are frequently observed following pancreatic cancer resection, but an improved understanding of resection margin assessment is required to aid tailored therapies. - Methods: Analyses were carried out to assess the association bet...

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Hauptverfasser: Ghaneh, Paula (VerfasserIn) , Kleeff, Jörg H. (VerfasserIn) , Halloran, Christopher M. (VerfasserIn) , Raraty, Michael (VerfasserIn) , Jackson, Richard (VerfasserIn) , Melling, James (VerfasserIn) , Jones, Owain (VerfasserIn) , Palmer, Daniel H. (VerfasserIn) , Cox, Trevor F. (VerfasserIn) , Smith, Chloe J. (VerfasserIn) , O'Reilly, Derek A. (VerfasserIn) , Izbicki, Jakob R. (VerfasserIn) , Scarfe, Andrew G. (VerfasserIn) , Valle, Juan W. (VerfasserIn) , McDonald, Alexander C. (VerfasserIn) , Carter, Ross (VerfasserIn) , Tebbutt, Niall C. (VerfasserIn) , Goldstein, David (VerfasserIn) , Padbury, Robert (VerfasserIn) , Shannon, Jennifer (VerfasserIn) , Dervenis, Christos G. (VerfasserIn) , Glimelius, Bengt (VerfasserIn) , Deakin, Mark (VerfasserIn) , Anthoney, Alan (VerfasserIn) , Lerch, Markus M. (VerfasserIn) , Mayerle, Julia (VerfasserIn) , Oláh, Attila (VerfasserIn) , Rawcliffe, Charlotte L. (VerfasserIn) , Campbell, Fiona (VerfasserIn) , Strobel, Oliver (VerfasserIn) , Büchler, Markus W. (VerfasserIn) , Neoptolemos, John P. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2019
In: Annals of surgery
Year: 2019, Jahrgang: 269, Heft: 3, Pages: 520-529
ISSN:1528-1140
DOI:10.1097/SLA.0000000000002557
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/SLA.0000000000002557
Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/annalsofsurgery/fulltext/2019/03000/The_Impact_of_Positive_Resection_Margins_on.22.aspx
Volltext
Verfasserangaben:Paula Ghaneh, MD, Jorg Kleeff, MD, Christopher M. Halloran, MD, Michael Raraty, MD, Richard Jackson, PhD,J ames Melling, MD, Owain Jones, MD, Daniel H. Palmer, MD, Trevor F. Cox, PhD, Chloe J. Smith, MSc, Derek A. O’Reilly, MD, Jakob R. Izbicki, MD, Andrew G. Scarfe, MD, Juan W. Valle, MD, Alexander C. McDonald, MD, Ross Carter, MD, Niall C. Tebbutt, PhD, David Goldstein, MB, Robert Padbury, MB, Jennifer Shannon, PhD, FRACP, Christos Dervenis, MD, Bengt Glimelius, MD, Mark Deakin, MD, Alan Anthoney, MD, Markus M. Lerch, MD, Julia Mayerle, MD, Attila Oláh, MD, Charlotte L. Rawcliffe, MSc,Fiona Campbell, MD, Oliver Strobel, MD, Markus W. Büchler, MD, and John P. Neoptolemos, MD, for the European Study Group for Pancreatic Cancer
Beschreibung
Zusammenfassung:Objective and Background: Local and distant disease recurrence are frequently observed following pancreatic cancer resection, but an improved understanding of resection margin assessment is required to aid tailored therapies. - Methods: Analyses were carried out to assess the association between clinical characteristics and margin involvement as well as the effects of individual margin involvement on site of recurrence and overall and recurrence-free survival using individual patient data from the European Study Group for Pancreatic Cancer (ESPAC)-3 randomized controlled trial. - Results: There were 1151 patients, of whom 505 (43.9%) had an R1 resection. The median and 95% confidence interval (CI) overall survival was 24.9 (22.9-27.2) months for 646 (56.1%) patients with resection margin negative (R0 >1 mm) tumors, 25.4 (21.6-30.4) months for 146 (12.7%) patients with R1<1 mm positive resection margins, and 18.7 (17.2-21.1) months for 359 (31.2%) patients with R1-direct positive margins (P < 0.001). In multivariable analysis, overall R1-direct tumor margins, poor tumor differentiation, positive lymph node status, WHO performance status ≥1, maximum tumor size, and R1-direct posterior resection margin were all independently significantly associated with reduced overall and recurrence-free survival. Competing risks analysis showed that overall R1-direct positive resection margin status, positive lymph node status, WHO performance status 1, and R1-direct positive superior mesenteric/medial margin resection status were all significantly associated with local recurrence. - Conclusions: R1-direct resections were associated with significantly reduced overall and recurrence-free survival following pancreatic cancer resection. Resection margin involvement was also associated with an increased risk for local recurrence.
Beschreibung:Gesehen am 26.03.2020
Beschreibung:Online Resource
ISSN:1528-1140
DOI:10.1097/SLA.0000000000002557

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