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Enhanced expression of thioredoxin-interacting-protein regulates oxidative DNA damage and aging

The “free radical theory of aging” suggests that reactive oxygen species (ROS) are responsible for age-related loss of cellular functions and, therefore, represent the main cause of aging. Redox regulation by thioredoxin-1 (TRX) plays a crucial role in responses to oxidative stress. We show that thi...

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Main Authors: Oberacker, Tina (Author) , Bajorat, Jörg (Author) , Ziola, Sabine (Author) , Schroeder, Anne (Author) , Röth, Daniel (Author) , Kastl, Lena (Author) , Edgar, Bruce A. (Author) , Wagner, Wolfgang (Author) , Gülow, Karsten (Author) , Krammer, Peter H. (Author)
Format: Article (Journal)
Language:English
Published: 27 June 2018
In: FEBS letters
Year: 2018, Volume: 592, Issue: 13, Pages: 2297-2307
ISSN:1873-3468
DOI:10.1002/1873-3468.13156
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/1873-3468.13156
Verlag, lizenzpflichtig, Volltext: https://febs.onlinelibrary.wiley.com/doi/abs/10.1002/1873-3468.13156
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Author Notes:Tina Oberacker, Jörg Bajorat, Sabine Ziola, Anne Schroeder, Daniel Röth, Lena Kastl, Bruce A. Edgar, Wolfgang Wagner, Karsten Gülow and Peter H. Krammer
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Summary:The “free radical theory of aging” suggests that reactive oxygen species (ROS) are responsible for age-related loss of cellular functions and, therefore, represent the main cause of aging. Redox regulation by thioredoxin-1 (TRX) plays a crucial role in responses to oxidative stress. We show that thioredoxin-interacting protein (TXNIP), a negative regulator of TRX, plays a major role in maintaining the redox status and, thereby, influences aging processes. This role of TXNIP is conserved from flies to humans. Age-dependent upregulation of TXNIP results in decreased stress resistance to oxidative challenge in primary human cells and in Drosophila. Experimental overexpression of TXNIP in flies shortens lifespan due to elevated oxidative DNA damage, whereas downregulation of TXNIP enhances oxidative stress resistance and extends lifespan.
Item Description:Gesehen am 25.03.2020
Physical Description:Online Resource
ISSN:1873-3468
DOI:10.1002/1873-3468.13156

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