Identification of prognostic DNA methylation biomarkers in patients with gastrointestinal adenocarcinomas: A systematic review of epigenome-wide studies
This systematic review aims to summarize epigenome-wide studies on aberrant DNA methylation and its association with survival in patients with gastrointestinal adenocarcinoma. The 15 studies identified showed a large variety of methodological approaches for the identification of prognostic epigeneti...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2020
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| In: |
Cancer treatment reviews
Year: 2020, Volume: 82 |
| ISSN: | 1532-1967 |
| DOI: | 10.1016/j.ctrv.2019.101933 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ctrv.2019.101933 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0305737219301549 
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| Author Notes: | Margherita d'Errico, Elizabeth Alwers, Yan Zhang, Dominic Edelmann, Hermann Brenner, Michael Hoffmeister |
| Summary: | This systematic review aims to summarize epigenome-wide studies on aberrant DNA methylation and its association with survival in patients with gastrointestinal adenocarcinoma. The 15 studies identified showed a large variety of methodological approaches for the identification of prognostic epigenetic markers from genome-wide methylation analyses. None of the findings were reported by more than one study in this systematic review. Further validation studies, a better reporting of methods and results are needed, as well as a clearer definition of investigated outcomes. At present, no conclusions can be drawn on the clinical relevance of the reported epigenetic markers. |
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| Item Description: | Available online 23 November 2019 Gesehen am 26.03.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1532-1967 |
| DOI: | 10.1016/j.ctrv.2019.101933 |