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MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments

The ErbB3 receptor binding protein Ebp1 binds to ribosomes and is linked to translational control. Here, the authors present the cryo-EM structure of human Ebp1 bound to a non-translating 80S ribosome and find that Ebp1 blocks the tunnel exit and recruits the rRNA expansion segment ES27L to the tunn...

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Bibliographic Details
Main Authors: Wild, Klemens (Author) , Aleksić, Milan (Author) , Lapouge, Karine (Author) , Juaire, Keven D. (Author) , Flemming, Dirk (Author) , Pfeffer, Stefan (Author) , Sinning, Irmgard (Author)
Format: Article (Journal)
Language:English
Published: 07 February 2020
In: Nature Communications
Year: 2020, Volume: 11
ISSN:2041-1723
DOI:10.1038/s41467-020-14603-7
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-020-14603-7
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-020-14603-7
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Author Notes:Klemens Wild, Milan Aleksić, Karine Lapouge, Keven D. Juaire, Dirk Flemming, Stefan Pfeffer & Irmgard Sinning
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Summary:The ErbB3 receptor binding protein Ebp1 binds to ribosomes and is linked to translational control. Here, the authors present the cryo-EM structure of human Ebp1 bound to a non-translating 80S ribosome and find that Ebp1 blocks the tunnel exit and recruits the rRNA expansion segment ES27L to the tunnel exit.
Item Description:Gesehen am 27.03.2020
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-020-14603-7

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