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Neuronal ensemble-specific DNA methylation strengthens engram stability

Memories are encoded within neuronal ensembles activated during learning. Here the authors show that DNA methylation within neuronal ensembles contributes to the stability of the memory trace, and increases the likelihood of neuronal ensemble reactivation during retrieval.

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Bibliographic Details
Main Authors: Gülmez Karaca, Kübra (Author) , Kupke, Janina (Author) , Brito, David V. C. (Author) , Zeuch, Benjamin (Author) , Thome, Christian (Author) , Weichenhan, Dieter (Author) , Lutsik, Pavlo (Author) , Plass, Christoph (Author) , Oliveira, Ana (Author)
Format: Article (Journal)
Language:English
Published: 31 January 2020
In: Nature Communications
Year: 2020, Volume: 11, Pages: 1-13
ISSN:2041-1723
DOI:10.1038/s41467-020-14498-4
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-020-14498-4
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-020-14498-4
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Author Notes:Kubra Gulmez Karaca, Janina Kupke, David V.C. Brito, Benjamin Zeuch, Christian Thome, Dieter Weichenhan, Pavlo Lutsik, Christoph Plass & Ana M.M. Oliveira
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Summary:Memories are encoded within neuronal ensembles activated during learning. Here the authors show that DNA methylation within neuronal ensembles contributes to the stability of the memory trace, and increases the likelihood of neuronal ensemble reactivation during retrieval.
Item Description:Gesehen am 30.03.2020
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-020-14498-4

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