Site-specific one-pot triple click labeling for DNA and RNA
We report site-specific triple click labeling for DNA and RNA in a one-pot setup by performing inverse electron demand Diels-Alder reaction and strain-promoted and copper catalyzed click reactions sequentially. Our methodology can be applied to long and short nucleic acids alike, and could have broa...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
26 Sep 2018
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| In: |
Chemical communications
Year: 2018, Volume: 54, Issue: 83, Pages: 11781-11784 |
| ISSN: | 1364-548X |
| DOI: | 10.1039/C8CC04520H |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1039/C8CC04520H Verlag, lizenzpflichtig, Volltext: https://pubs.rsc.org/en/content/articlelanding/2018/cc/c8cc04520h 
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| Author Notes: | Marie-Luise Winz, Eva Christina Linder, Juliane Becker and Andres Jäschke |
| Summary: | We report site-specific triple click labeling for DNA and RNA in a one-pot setup by performing inverse electron demand Diels-Alder reaction and strain-promoted and copper catalyzed click reactions sequentially. Our methodology can be applied to long and short nucleic acids alike, and could have broader potential for labeling other (bio-)molecules. |
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| Item Description: | Gesehen am 31.03.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1364-548X |
| DOI: | 10.1039/C8CC04520H |