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Efficacy of Bifidobacterium longum, B. infantis and Lactobacillus acidophilus probiotics to prevent gut dysbiosis in preterm infants of 28+0-32+6 weeks of gestation: a randomised, placebo-controlled, double-blind, multicentre trial : the PRIMAL Clinical Study protocol

Introduction: The healthy ‘eubiosis’ microbiome in infancy is regarded as the microbiome derived from term, vaginally delivered, antibiotic free, breastfed infants at 4-6 months. Dysbiosis is regarded as a deviation from a healthy state with reduced microbial diversity and deficient capacity to cont...

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Bibliographic Details
Main Authors: Marißen, Janina (Author) , Hudalla, Hannes (Author) , Bork, Peer (Author)
Format: Article (Journal)
Language:English
Published: November 21, 2019
In: BMJ open
Year: 2019, Volume: 9, Issue: 11
ISSN:2044-6055
DOI:10.1136/bmjopen-2019-032617
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1136/bmjopen-2019-032617
Verlag, lizenzpflichtig, Volltext: https://bmjopen.bmj.com/content/9/11/e032617
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Author Notes:Janina Marißen, Annette Haiß, Claudius Meyer, Thea Van Rossum, Lisa Marie Bünte, David Frommhold, Christian Gille, Sybelle Goedicke-Fritz, Wolfgang Göpel, Hannes Hudalla, Julia Pagel, Sabine Pirr, Bastian Siller, Dorothee Viemann, Maren Vens, Inke König, Egbert Herting, Michael Zemlin, Stephan Gehring, Peer Bork, Philipp Henneke, Christoph Härtel, for the behalf for the PRIMAL consortium
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Summary:Introduction: The healthy ‘eubiosis’ microbiome in infancy is regarded as the microbiome derived from term, vaginally delivered, antibiotic free, breastfed infants at 4-6 months. Dysbiosis is regarded as a deviation from a healthy state with reduced microbial diversity and deficient capacity to control drug-resistant organisms. Preterm infants are highly sensitive to early gut dysbiosis. Latter has been associated with sepsis and necrotising enterocolitis, but may also contribute to long-term health problems. Probiotics hold promise to reduce the risk for adverse short-term outcomes but the evidence from clinical trials remains inconclusive and none has directly assessed the effects of probiotics on the microbiome at high resolution.
Item Description:Gesehen am 31.03.2020
Physical Description:Online Resource
ISSN:2044-6055
DOI:10.1136/bmjopen-2019-032617

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