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Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model

The amyloid-β (Aβ) peptide, the primary constituent of amyloid plaques found in Alzheimer’s disease (AD) brains, is derived from sequential proteolytic processing of the Amyloid Precursor Protein (APP). However, the contribution of different cell types to Aβ deposition has not yet been examined in a...

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Main Authors: Rice, Heather (Author) , Marcassa, Gabriele (Author) , Chrysidou, Iordana (Author) , Horré, Katrien (Author) , Young-Pearse, Tracy L. (Author) , Müller, Ulrike C. (Author) , Saito, Takashi (Author) , Saido, Takaomi C. (Author) , Vassar, Robert (Author) , de Wit, Joris (Author) , De Strooper, Bart (Author)
Format: Article (Journal)
Language:English
Published: 08 January 2020
In: Molecular neurodegeneration
Year: 2020, Volume: 15, Issue: 1
ISSN:1750-1326
DOI:10.1186/s13024-019-0356-y
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13024-019-0356-y
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Author Notes:Heather C. Rice, Gabriele Marcassa, Iordana Chrysidou, Katrien Horré, Tracy L. Young-Pearse, Ulrike C. Müller, Takashi Saito, Takaomi C. Saido, Robert Vassar, Joris de Wit and Bart De Strooper
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Summary:The amyloid-β (Aβ) peptide, the primary constituent of amyloid plaques found in Alzheimer’s disease (AD) brains, is derived from sequential proteolytic processing of the Amyloid Precursor Protein (APP). However, the contribution of different cell types to Aβ deposition has not yet been examined in an in vivo, non-overexpression system. Here, we show that endogenous APP is highly expressed in a heterogeneous subset of GABAergic interneurons throughout various laminae of the hippocampus, suggesting that these cells may have a profound contribution to AD plaque pathology.
Item Description:Gesehen am 01.04.2020
Physical Description:Online Resource
ISSN:1750-1326
DOI:10.1186/s13024-019-0356-y

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