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Eosinophil accumulation predicts response to melanoma treatment with immune checkpoint inhibitors

Eosinophils have been identified as a prognostic marker in immunotherapy of melanoma and suggested to contribute to anti-tumor host defense. However, the influence of immune checkpoint inhibitors (ICI) on the eosinophil population is poorly studied. Here, we applied routine laboratory tests, multico...

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Bibliographic Details
Main Authors: Simon, Sonja C. S. (Author) , Hu, Xiaoying (Author) , Panten, Jasper (Author) , Grees, Mareike (Author) , Renders, Simon (Author) , Thomas, Daniel (Author) , Bitsch, Rebekka (Author) , Schulze, Torsten J. (Author) , Utikal, Jochen (Author) , Umansky, Viktor (Author)
Format: Article (Journal)
Language:English
Published: 15 Feb 2020
In: OncoImmunology
Year: 2020, Volume: 9
ISSN:2162-402X
DOI:10.1080/2162402X.2020.1727116
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1080/2162402X.2020.1727116
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Author Notes:Sonja C.S. Simon, Xiaoying Hu, Jasper Panten, Mareike Grees, Simon Renders, Daniel Thomas, Rebekka Weber, Torsten J. Schulze, Jochen Utikal & Viktor Umansky
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Summary:Eosinophils have been identified as a prognostic marker in immunotherapy of melanoma and suggested to contribute to anti-tumor host defense. However, the influence of immune checkpoint inhibitors (ICI) on the eosinophil population is poorly studied. Here, we applied routine laboratory tests, multicolor flow cytometry, RNA microarray analysis, and bio-plex assay to analyze circulating eosinophils and related serum inflammatory factors in 32 patients treated with pembrolizumab or the combination of nivolumab and ipilimumab.
Item Description:Gesehen am 02.04.2020
Physical Description:Online Resource
ISSN:2162-402X
DOI:10.1080/2162402X.2020.1727116

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