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Eosinophil accumulation predicts response to melanoma treatment with immune checkpoint inhibitors

Eosinophils have been identified as a prognostic marker in immunotherapy of melanoma and suggested to contribute to anti-tumor host defense. However, the influence of immune checkpoint inhibitors (ICI) on the eosinophil population is poorly studied. Here, we applied routine laboratory tests, multico...

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Hauptverfasser: Simon, Sonja C. S. (VerfasserIn) , Hu, Xiaoying (VerfasserIn) , Panten, Jasper (VerfasserIn) , Grees, Mareike (VerfasserIn) , Renders, Simon (VerfasserIn) , Thomas, Daniel (VerfasserIn) , Bitsch, Rebekka (VerfasserIn) , Schulze, Torsten J. (VerfasserIn) , Utikal, Jochen (VerfasserIn) , Umansky, Viktor (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 15 Feb 2020
In: OncoImmunology
Year: 2020, Jahrgang: 9
ISSN:2162-402X
DOI:10.1080/2162402X.2020.1727116
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1080/2162402X.2020.1727116
Volltext
Verfasserangaben:Sonja C.S. Simon, Xiaoying Hu, Jasper Panten, Mareike Grees, Simon Renders, Daniel Thomas, Rebekka Weber, Torsten J. Schulze, Jochen Utikal & Viktor Umansky
Beschreibung
Zusammenfassung:Eosinophils have been identified as a prognostic marker in immunotherapy of melanoma and suggested to contribute to anti-tumor host defense. However, the influence of immune checkpoint inhibitors (ICI) on the eosinophil population is poorly studied. Here, we applied routine laboratory tests, multicolor flow cytometry, RNA microarray analysis, and bio-plex assay to analyze circulating eosinophils and related serum inflammatory factors in 32 patients treated with pembrolizumab or the combination of nivolumab and ipilimumab.
Beschreibung:Gesehen am 02.04.2020
Beschreibung:Online Resource
ISSN:2162-402X
DOI:10.1080/2162402X.2020.1727116

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