Cover Image

Estimation of the α/β ratio of non-small cell lung cancer treated with stereotactic body radiotherapy

High-dose hypofractionated radiotherapy should theoretically result in a deviation from the typical linear-quadratic shape of the cell survival curve beyond a certain threshold dose, yet no evidence for this hypothesis has so far been found in clinical data of stereotactic body radiotherapy treatmen...

Full description

Saved in:
Bibliographic Details
Main Authors: Klement, Rainer J. (Author) , Sonke, Jan-Jakob (Author) , Allgäuer, Michael (Author) , Andratschke, Nicolaus (Author) , Appold, Steffen (Author) , Belderbos, José (Author) , Belka, Claus (Author) , Dieckmann, Karin (Author) , Eich, Hans T. (Author) , Flentje, Michael (Author) , Grills, Inga (Author) , Eble, Michael (Author) , Hope, Andrew (Author) , Grosu, Anca L. (Author) , Semrau, Sabine (Author) , Sweeney, Reinhart A. (Author) , Hörner-Rieber, Juliane (Author) , Werner-Wasik, Maria (Author) , Engenhart-Cabillic, Rita (Author) , Ye, Hong (Author) , Guckenberger, Matthias (Author)
Format: Article (Journal)
Language:English
Published: 2020
In: Radiotherapy and oncology
Year: 2019, Volume: 142, Pages: 210-216
ISSN:1879-0887
DOI:10.1016/j.radonc.2019.07.008
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.radonc.2019.07.008
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0167814019329986
Get full text
Author Notes:Rainer J. Klement, Jan-Jakob Sonke, Michael Allgäuer, Nicolaus Andratschke, Steffen Appold, José Belderbos, Claus Belka, Karin Dieckmann, Hans T. Eich, Michael Flentje, Inga Grills, Michael Eble, Andrew Hope, Anca L. Grosu, Sabine Semrau, Reinhart A. Sweeney, Juliane Hörner-Rieber, Maria Werner-Wasik, Rita Engenhart-Cabillic, Hong Ye, Matthias Guckenberger
Description
Summary:High-dose hypofractionated radiotherapy should theoretically result in a deviation from the typical linear-quadratic shape of the cell survival curve beyond a certain threshold dose, yet no evidence for this hypothesis has so far been found in clinical data of stereotactic body radiotherapy treatment (SBRT) for early-stage non-small cell lung cancer (NSCLC). A pragmatic explanation is a larger α/β ratio than the conventionally assumed 10Gy. We here attempted an estimation of the α/β ratio for NSCLC treated with SBRT using individual patient data.
Item Description:Available online 17 August 2019
Gesehen am 02.04.2020
Physical Description:Online Resource
ISSN:1879-0887
DOI:10.1016/j.radonc.2019.07.008

Similar Items