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Evaluation of the anti-Thomsen-Friedenreich antibodies Nemod-TF1 and Nemod-TF2 as prognostic markers in breast cancer

The TF (Thomsen-Friedenreich, CD176, Galβ1-3GalNAc) carbohydrate moiety is known as a specific oncofetal carbohydrate epitope present in fetal and neoplastic tissue as well as in stem cells. TF was demonstrated to mediate tumor-promoting features and to be highly immunogenic. The current study aimed...

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Main Authors: Heublein, Sabine (Author) , Egger, Markus (Author) , Zhu, Junyan (Author) , Berger, Luisa (Author) , Mayr, Doris (Author) , Schindlbeck, Christian (Author) , Kuhn, Christina (Author) , Hofmann, Simone S. (Author) , Schütz, Florian (Author) , Jeschke, Udo (Author) , Ditsch, Nina (Author)
Format: Article (Journal)
Language:English
Published: 2020
In: Breast cancer research and treatment
Year: 2020, Volume: 179, Issue: 3, Pages: 643-652
ISSN:1573-7217
DOI:10.1007/s10549-019-05503-6
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1007/s10549-019-05503-6
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Author Notes:Sabine Heublein, Markus Egger, Junyan Zhu, Luisa Berger, Doris Mayr, Christian Schindlbeck, Christina Kuhn, Simone S. Hofmann, Florian Schuetz, Udo Jeschke, Nina Ditsch
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Summary:The TF (Thomsen-Friedenreich, CD176, Galβ1-3GalNAc) carbohydrate moiety is known as a specific oncofetal carbohydrate epitope present in fetal and neoplastic tissue as well as in stem cells. TF was demonstrated to mediate tumor-promoting features and to be highly immunogenic. The current study aimed to evaluate whether presence of the TF antigen is associated with clinico-pathological parameters and prognosis of early breast cancer (BC).
Item Description:Published online: 11 December 2019
Gesehen am 02.04.2020
Physical Description:Online Resource
ISSN:1573-7217
DOI:10.1007/s10549-019-05503-6

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