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Evaluation of the anti-Thomsen-Friedenreich antibodies Nemod-TF1 and Nemod-TF2 as prognostic markers in breast cancer

The TF (Thomsen-Friedenreich, CD176, Galβ1-3GalNAc) carbohydrate moiety is known as a specific oncofetal carbohydrate epitope present in fetal and neoplastic tissue as well as in stem cells. TF was demonstrated to mediate tumor-promoting features and to be highly immunogenic. The current study aimed...

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Hauptverfasser: Heublein, Sabine (VerfasserIn) , Egger, Markus (VerfasserIn) , Zhu, Junyan (VerfasserIn) , Berger, Luisa (VerfasserIn) , Mayr, Doris (VerfasserIn) , Schindlbeck, Christian (VerfasserIn) , Kuhn, Christina (VerfasserIn) , Hofmann, Simone S. (VerfasserIn) , Schütz, Florian (VerfasserIn) , Jeschke, Udo (VerfasserIn) , Ditsch, Nina (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2020
In: Breast cancer research and treatment
Year: 2020, Jahrgang: 179, Heft: 3, Pages: 643-652
ISSN:1573-7217
DOI:10.1007/s10549-019-05503-6
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1007/s10549-019-05503-6
Volltext
Verfasserangaben:Sabine Heublein, Markus Egger, Junyan Zhu, Luisa Berger, Doris Mayr, Christian Schindlbeck, Christina Kuhn, Simone S. Hofmann, Florian Schuetz, Udo Jeschke, Nina Ditsch
Beschreibung
Zusammenfassung:The TF (Thomsen-Friedenreich, CD176, Galβ1-3GalNAc) carbohydrate moiety is known as a specific oncofetal carbohydrate epitope present in fetal and neoplastic tissue as well as in stem cells. TF was demonstrated to mediate tumor-promoting features and to be highly immunogenic. The current study aimed to evaluate whether presence of the TF antigen is associated with clinico-pathological parameters and prognosis of early breast cancer (BC).
Beschreibung:Published online: 11 December 2019
Gesehen am 02.04.2020
Beschreibung:Online Resource
ISSN:1573-7217
DOI:10.1007/s10549-019-05503-6

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