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A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism

Despite widespread transcription of LncRNA in mammalian systems, their contribution to metabolic homeostasis at the cellular and tissue level remains elusive. Here Pradas-Juni et al. describe a transcription factor-LncRNA pathway that couples hepatocyte nutrient sensing to regulation of glucose meta...

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Main Authors: Pradas-Juni, Marta (Author) , Hansmeier, Nils R. (Author) , Link, Jenny C. (Author) , Schmidt, Elena (Author) , Larsen, Bjørk Ditlev (Author) , Klemm, Paul (Author) , Meola, Nicola (Author) , Topel, Hande (Author) , Loureiro, Rute (Author) , Dhaouadi, Ines (Author) , Kiefer, Christoph A. (Author) , Schwarzer, Robin (Author) , Khani, Sajjad (Author) , Oliverio, Matteo (Author) , Awazawa, Motoharu (Author) , Frommolt, Peter (Author) , Heeren, Joerg (Author) , Scheja, Ludger (Author) , Heine, Markus (Author) , Dieterich, Christoph (Author) , Büning, Hildegard (Author) , Yang, Ling (Author) , Cao, Haiming (Author) , Jesus, Dario F. De (Author) , Kulkarni, Rohit N. (Author) , Zevnik, Branko (Author) , Tröder, Simon E. (Author) , Knippschild, Uwe (Author) , Edwards, Peter A. (Author) , Lee, Richard G. (Author) , Yamamoto, Masayuki (Author) , Ulitsky, Igor (Author) , Fernandez-Rebollo, Eduardo (Author) , Vallim, Thomas Q. de Aguiar (Author) , Kornfeld, Jan-Wilhelm (Author)
Format: Article (Journal)
Language:English
Published: 31 January 2020
In: Nature Communications
Year: 2020, Volume: 11
ISSN:2041-1723
DOI:10.1038/s41467-020-14323-y
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-020-14323-y
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-020-14323-y
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Author Notes:Marta Pradas-Juni, Nils R. Hansmeier, Jenny C. Link, Elena Schmidt, Bjørk Ditlev Larsen, Paul Klemm, Nicola Meola, Hande Topel, Rute Loureiro, Ines Dhaouadi, Christoph A. Kiefer, Robin Schwarzer, Sajjad Khani, Matteo Oliverio, Motoharu Awazawa, Peter Frommolt, Joerg Heeren, Ludger Scheja, Markus Heine, Christoph Dieterich, Hildegard Büning, Ling Yang, Haiming Cao, Dario F. De Jesus, Rohit N. Kulkarni, Branko Zevnik, Simon E. Tröder, Uwe Knippschild, Peter A. Edwards, Richard G. Lee, Masayuki Yamamoto, Igor Ulitsky, Eduardo Fernandez-Rebollo, Thomas Q. de Aguiar Vallim, Jan-Wilhelm Kornfeld
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Summary:Despite widespread transcription of LncRNA in mammalian systems, their contribution to metabolic homeostasis at the cellular and tissue level remains elusive. Here Pradas-Juni et al. describe a transcription factor-LncRNA pathway that couples hepatocyte nutrient sensing to regulation of glucose metabolism in mice.
Item Description:Gesehen am 02.04.2020
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-020-14323-y

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