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FOCAD loss impacts microtubule assembly, G2/M progression and patient survival in astrocytic gliomas

In search of novel genes associated with glioma pathogenesis, we have previously shown frequent deletions of the KIAA1797/FOCAD gene in malignant gliomas, and a tumor suppressor function of the encoded focadhesin impacting proliferation and migration of glioma cells in vitro and in vivo. Here, we ex...

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Main Authors: Brand, Frank (Author) , Förster, Alisa (Author) , Christians, Anne (Author) , Bucher, Martin (Author) , Thomé, Carina M. (Author) , Raab, Marc-Steffen (Author) , Westphal, Manfred (Author) , Pietsch, Torsten (Author) , Deimling, Andreas von (Author) , Reifenberger, Guido (Author) , Claus, Peter (Author) , Hentschel, Bettina (Author) , Weller, Michael (Author) , Weber, Ruthild G. (Author)
Format: Article (Journal)
Language:English
Published: 2020
In: Acta neuropathologica
Year: 2019, Volume: 139, Issue: 1, Pages: 175-192
ISSN:1432-0533
DOI:10.1007/s00401-019-02067-z
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00401-019-02067-z
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Author Notes:Frank Brand, Alisa Förster, Anne Christians, Martin Bucher, Carina M. Thomé, Marc S. Raab, Manfred Westphal, Torsten Pietsch, Andreas von Deimling, Guido Reifenberger, Peter Claus, Bettina Hentschel, Michael Weller, Ruthild G. Weber
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Summary:In search of novel genes associated with glioma pathogenesis, we have previously shown frequent deletions of the KIAA1797/FOCAD gene in malignant gliomas, and a tumor suppressor function of the encoded focadhesin impacting proliferation and migration of glioma cells in vitro and in vivo. Here, we examined an association of reduced FOCAD gene copy number with overall survival of patients with astrocytic gliomas, and addressed the molecular mechanisms that govern the suppressive effect of focadhesin on glioma growth.
Item Description:Published online: 31 August 2019
Gesehen am 02.04.2020
Physical Description:Online Resource
ISSN:1432-0533
DOI:10.1007/s00401-019-02067-z

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