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Wall contrast enhancement of thrombosed intracranial aneurysms at 7T MRI

BACKGROUND AND PURPOSE: The pathophysiology of wall contrast enhancement in thrombosed intracranial aneurysms is incompletely understood. This in vivo study aimed to investigate wall microstructures with gadolinium-enhanced 7T MR imaging. MATERIALS AND METHODS: Thirteen patients with 14 thrombosed i...

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Main Authors: Sato, Taku (Author) , Matsushige, Toshinori (Author) , Chen, Bixia (Author) , Gembruch, O. (Author) , Dammann, P. (Author) , Jabbarli, R. (Author) , Forsting, M. (Author) , Junker, A. (Author) , Maderwald, S. (Author) , Quick, H.H. (Author) , Ladd, Mark E. (Author) , Sure, U. (Author) , Wrede, K.H. (Author)
Format: Article (Journal)
Language:English
Published: July 8, 2019
In: American journal of neuroradiology
Year: 2019, Volume: 40, Issue: 7, Pages: 1106-1111
ISSN:1936-959X
DOI:10.3174/ajnr.A6084
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3174/ajnr.A6084
Verlag, lizenzpflichtig, Volltext: http://www.ajnr.org/lookup/doi/10.3174/ajnr.A6084
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Author Notes:T. Sato, T. Matsushige, B. Chen, O. Gembruch, P. Dammann, R. Jabbarli, M. Forsting, A. Junker, S. Maderwald, H.H. Quick, M.E. Ladd, U. Sure, K.H. Wrede
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Summary:BACKGROUND AND PURPOSE: The pathophysiology of wall contrast enhancement in thrombosed intracranial aneurysms is incompletely understood. This in vivo study aimed to investigate wall microstructures with gadolinium-enhanced 7T MR imaging. MATERIALS AND METHODS: Thirteen patients with 14 thrombosed intracranial aneurysms were evaluated using a 7T whole-body MR imaging system with nonenhanced and gadolinium-enhanced high-resolution MPRAGE. Tissue samples were available in 5 cases, and histopathologic findings were correlated with 7T MR imaging to identify the gadolinium-enhancing microstructures. - RESULTS: Partial or complete inner wall enhancement correlated with neovascularization of the inner wall layer and the adjacent thrombus. Additional partial or complete outer wall enhancement can be explained by formation of vasa vasorum in the outer aneurysm wall layer. The double-rim enhancement correlated with perifocal edema and wall histologic findings suggestive of instability. - CONCLUSIONS: Two distinct aneurysm wall microstructures responsible for gadolinium enhancement not depictable at lower spatial resolutions can be visualized in vivo using high-resolution gadolinium-enhanced 7T MR imaging.
Item Description:Gesehen am 02.04.2020
Physical Description:Online Resource
ISSN:1936-959X
DOI:10.3174/ajnr.A6084

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