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The UGT1A1*28 gene variant predicts long-term mortality in patients undergoing coronary angiography

<section class="abstract"><h2 class="abstractTitle text-title my-1" id="d791e2">Abstract</h2><div id="j_cclm-2017-0692_s_999_w2aab2b8c76b1b7b1aab1c16b1Aa" class="section"><h3 class="abstractTitle text-title my-1"...

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Bibliographic Details
Main Authors: Zulus, Barbara (Author) , Kleber, Marcus E. (Author) , März, Winfried (Author)
Format: Article (Journal)
Language:English
Published: 2018
In: Clinical chemistry and laboratory medicine
Year: 2017, Volume: 56, Issue: 4, Pages: 560-564
ISSN:1437-4331
DOI:10.1515/cclm-2017-0692
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1515/cclm-2017-0692
Verlag, lizenzpflichtig, Volltext: https://www.degruyterbrill.com/view/journals/cclm/56/4/article-p560.xml
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Author Notes:Barbara Zulus, Gerda Grünbacher, Marcus E. Kleber, Winfried März and Wilfried Renner
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Summary:<section class="abstract"><h2 class="abstractTitle text-title my-1" id="d791e2">Abstract</h2><div id="j_cclm-2017-0692_s_999_w2aab2b8c76b1b7b1aab1c16b1Aa" class="section"><h3 class="abstractTitle text-title my-1" id="d791e5">Background:</h3><p>Uridine diphosphate glycosyltransferases 1A1 (UGT1A1) plays an essential role in detoxification and excretion of several endogenous and exogenous compounds. A functional polymorphism in the promoter of the <em>UGT1A1</em> gene (TA repeat insertion, <em>UGT1A1</em>*28, rs3064744) has been associated with reduced <em>UGT1A1</em> enzyme activity. The purpose of the present study was to investigate the role of <em>UGT1A1</em> genotypes in mortality.</p></div><div id="j_cclm-2017-0692_s_998_w2aab2b8c76b1b7b1aab1c16b2Aa" class="section"><h3 class="abstractTitle text-title my-1" id="d791e21">Methods:</h3><p><em>UGT1A1</em> genotypes as well as baseline plasma bilirubin levels were analyzed in participants of the Ludwigshafen Risk and Cardiovascular Health study (n=3316). <em>UGT1A1</em>*28 genotypes were determined on an ABI PRISM 3730 genetic analyzer.</p></div><div id="j_cclm-2017-0692_s_997_w2aab2b8c76b1b7b1aab1c16b3Aa" class="section"><h3 class="abstractTitle text-title my-1" id="d791e30">Results:</h3><p>As expected, <em>UGT1A1</em> genotypes were associated with baseline bilirubin levels (*1/*1 genotype: 9.1±4.6 µmol/L; *1/*28 genotype: 10.8±5.3; *28/*28: 16.9±9.2; p<0.001). During a median follow-up of 10.4 years, 995 subjects (30.0%) died. In a multivariate regression analysis adjusting for age, sex, smoking, type 2 diabetes, dyslipidemia, alanine aminotransferase (ALT) levels and bilirubin levels, the <em>UGT1A1</em>*28 variant predicted lower overall mortality (hazard ratio [HR], 0.86; 95% confidence interval [CI], 0.78-0.95; p=0.003). Contrary to expected, higher baseline bilirubin levels predicted increased mortality (HR, 1.014; 95% CI, 1.002-1.025; p=0.019).</p></div><div id="j_cclm-2017-0692_s_996_w2aab2b8c76b1b7b1aab1c16b4Aa" class="section"><h3 class="abstractTitle text-title my-1" id="d791e40">Conclusions:</h3><p>The <em>UGT1A1</em>*28 gene variant is associated with lower mortality rates. The protective effect of the <em>UGT1A1</em>*28 variant likely includes mechanism other than bilirubin metabolism.</p></div></section>
Item Description:published online December 7, 2017
Gesehen am 03.04.2020
Physical Description:Online Resource
ISSN:1437-4331
DOI:10.1515/cclm-2017-0692

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