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Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis

Antimicrobial peptide LL37 can bind nucleic acids and potentiate their sensing by endosomal TLRs. Here the authors show that LL37 binds to RNA from neutrophil extracellular traps (NETs), which amplifies inflammation and production of more LL37 and NETs via TLR8/13, suggesting that LL37 contribution...

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Main Authors: Herster, Franziska (Author) , Bittner, Zsofia (Author) , Archer, Nathan K. (Author) , Dickhöfer, Sabine (Author) , Eisel, David (Author) , Eigenbrod, Tatjana (Author) , Knorpp, Thomas (Author) , Schneiderhan-Marra, Nicole (Author) , Löffler, Markus W. (Author) , Kalbacher, Hubert (Author) , Vierbuchen, Tim (Author) , Heine, Holger (Author) , Miller, Lloyd S. (Author) , Hartl, Dominik (Author) , Freund, Lukas (Author) , Schäkel, Knut (Author) , Heister, Martin (Author) , Ghoreschi, Kamran (Author) , Weber, Alexander N. R. (Author)
Format: Article (Journal)
Language:English
Published: 08 January 2020
In: Nature Communications
Year: 2020, Volume: 11, Pages: 1-13
ISSN:2041-1723
DOI:10.1038/s41467-019-13756-4
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-019-13756-4
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-019-13756-4
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Author Notes:Franziska Herster, Zsofia Bittner, Nathan K. Archer, Sabine Dickhöfer, David Eisel, Tatjana Eigenbrod, Thomas Knorpp, Nicole Schneiderhan-Marra, Markus W. Löffler, Hubert Kalbacher, Tim Vierbuchen, Holger Heine, Lloyd S. Miller, Dominik Hartl, Lukas Freund, Knut Schäkel, Martin Heister, Kamran Ghoreschi & Alexander N.R. Weber
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Summary:Antimicrobial peptide LL37 can bind nucleic acids and potentiate their sensing by endosomal TLRs. Here the authors show that LL37 binds to RNA from neutrophil extracellular traps (NETs), which amplifies inflammation and production of more LL37 and NETs via TLR8/13, suggesting that LL37 contribution to psoriasis may be fueled by NET-associated RNA.
Item Description:Gesehen am 03.04.2020
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-019-13756-4

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