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New polynuclear 1,5-naphthyridine-silver(I) complexes as potential antimicrobial agents: the key role of the nature of donor coordinated to the metal center

New polynuclear silver(I) complexes with 1,5-naphthyridine (1,5-naph), [Ag(NO3)(1,5-naph)]n (Ag1), [Ag(CF3COO)(1,5-naph)]n (Ag2) and [Ag(CF3SO3)(1,5-naph)]n (Ag3) were synthesized by the reaction of the corresponding silver(I) salt and 1,5-naph in ethanol at room temperature. These complexes were ch...

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Main Authors: Đurić, Sonja Ž. (Author) , Vojnovic, Sandra (Author) , Pavic, Aleksandar (Author) , Mojicevic, Marija (Author) , Wadepohl, Hubert (Author) , Savić, Nada D. (Author) , Popsavin, Mirjana (Author) , Nikodinovic-Runic, Jasmina (Author) , Djuran, Miloš I. (Author) , Glišić, Biljana Đ. (Author)
Format: Article (Journal)
Language:English
Published: 2020
In: Journal of inorganic biochemistry
Year: 2019, Volume: 203
ISSN:1873-3344
DOI:10.1016/j.jinorgbio.2019.110872
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jinorgbio.2019.110872
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0162013419304878
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Author Notes:Sonja Đurić, Sandra Vojnovic, Aleksandar Pavic, Marija Mojicevic, Hubert Wadepohl, Nada D. Savić, Mirjana Popsavin, Jasmina Nikodinovic-Runic, Miloš I. Djuran, Biljana Đ. Glišić
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Summary:New polynuclear silver(I) complexes with 1,5-naphthyridine (1,5-naph), [Ag(NO3)(1,5-naph)]n (Ag1), [Ag(CF3COO)(1,5-naph)]n (Ag2) and [Ag(CF3SO3)(1,5-naph)]n (Ag3) were synthesized by the reaction of the corresponding silver(I) salt and 1,5-naph in ethanol at room temperature. These complexes were characterized by NMR, IR and UV-Vis spectroscopy, while their crystal structures were determined by single-crystal X-ray diffraction analysis. In all these complexes, 1,5-naph acts as a bridging ligand between two Ag(I) ions, while the remaining coordination sites are occupied by oxygen atom(s) of the corresponding anion. The antimicrobial efficiency of these silver(I) complexes was evaluated against the broad panel of Gram-positive and Gram-negative bacteria and fungi. The complexes showed good to moderate antibacterial activity with the minimal inhibitory concentration (MIC) values being in the range 2.5-100μg/mL (6.5-333.3μM), while their antifungal activity against the investigated Candida spp. was significantly higher (MIC=0.78-6.25μg/mL; 2.6-20.8μM). Moreover, complexes Ag1 and Ag2 effectively inhibited C. albicans biofilms formation, while Ag1 was also shown to inhibit the formation of mixed C. albicans/Pseudomonas aeruginosa biofilms. Toxicological evaluations on zebrafish (Danio rerio) embryos revealed that all silver(I) complexes could be applied as antifungal agents, whereas Ag3 had the best therapeutic potential showing both the lowest MIC values against the tested Candida strains and the non-toxic in vivo response in the zebrafish embryos at these doses.
Item Description:Available online 23 October 2019
Gesehen am 03.04.2020
Physical Description:Online Resource
ISSN:1873-3344
DOI:10.1016/j.jinorgbio.2019.110872

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