Asymmetric distribution of TLR3 leads to a polarized immune response in human intestinal epithelial cells

Viral infection from the basolateral side of intestinal epithelial cells (IECs) is shown to elicit a stronger intrinsic immune response than apical infection, an effect driven by the polarized sorting of Toll-like receptor 3. Experiments in mice and human cells suggest that the cellular polarity pro...

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Bibliographic Details

Main Authors:	Stanifer, Megan (Author) , Mukenhirn, Markus (Author) , Münchau, Stephanie (Author) , Pervolaraki, Kalliopi (Author) , Kanaya, Takashi (Author) , Albrecht, Dorothee (Author) , Odendall, Charlotte (Author) , Hielscher, Thomas (Author) , Haucke, Volker (Author) , Kagan, Jonathan C. (Author) , Bartfeld, Sina (Author) , Ohno, Hiroshi (Author) , Boulant, Steeve (Author)
Format:	Article (Journal)
Language:	English
Published:	2020
In:	Nature microbiology Year: 2020, Volume: 5, Issue: 1, Pages: 181-191
ISSN:	2058-5276
DOI:	10.1038/s41564-019-0594-3
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41564-019-0594-3 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41564-019-0594-3
Author Notes:	Megan L. Stanifer, Markus Mukenhirn, Stephanie Muenchau, Kalliopi Pervolaraki, Takashi Kanaya, Dorothee Albrecht, Charlotte Odendall, Thomas Hielscher, Volker Haucke, Jonathan C. Kagan, Sina Bartfeld, Hiroshi Ohno and Steeve Boulant