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Oncolytic measles virotherapy and opposition to measles vaccination

Recent measles epidemics in US and European cities where vaccination coverage has declined are providing a harsh reminder for the need to maintain protective levels of immunity across the entire population. Vaccine uptake rates have been declining in large part because of public misinformation regar...

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Main Authors: Russell, Stephen J. (Author) , Babovic-Vuksanovic, Dusica (Author) , Bexon, Alice (Author) , Cattaneo, Roberto (Author) , Dingli, David (Author) , Dispenzieri, Angela (Author) , Deyle, David R. (Author) , Federspiel, Mark J. (Author) , Fielding, Adele (Author) , Galanis, Evanthia (Author) , Lacy, Martha Q. (Author) , Leibovich, Bradley C. (Author) , Liu, Minetta C. (Author) , Muñoz-Alía, Miguel (Author) , Miest, Tanner C. (Author) , Molina, Julian R. (Author) , Mueller, Sabine (Author) , Okuno, Scott H. (Author) , Packiriswamy, Nandakumar (Author) , Peikert, Tobias (Author) , Raffel, Corey (Author) , Van Rhee, Frits (Author) , Ungerechts, Guy (Author) , Young, Paul R. (Author) , Zhou, Yumei (Author) , Peng, Kah-Whye (Author)
Format: Article (Journal)
Language:English
Published: 22 June 2019
In: Mayo Clinic proceedings
Year: 2019, Volume: 94, Issue: 9, Pages: 1834-1839
ISSN:1942-5546
DOI:10.1016/j.mayocp.2019.05.006
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.mayocp.2019.05.006
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0025619619304628
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Author Notes:Stephen J. Russell, Dusica Babovic-Vuksanovic, Alice Bexon, Roberto Cattaneo, David Dingli, Angela Dispenzieri, David R. Deyle, Mark J. Federspiel, Adele Fielding, Eva Galanis, Martha Q. Lacy, Bradley C. Leibovich, Minetta C. Liu, Miguel Muñoz-Alía, Tanner C. Miest, Julian R. Molina, Sabine Mueller, Scott H. Okuno, Nandakumar Packiriswamy, Tobias Peikert, Corey Raffel, Frits Van Rhee, Guy Ungerechts, Paul R. Young, Yumei Zhou, and Kah-Whye Peng
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Summary:Recent measles epidemics in US and European cities where vaccination coverage has declined are providing a harsh reminder for the need to maintain protective levels of immunity across the entire population. Vaccine uptake rates have been declining in large part because of public misinformation regarding a possible association between measles vaccination and autism for which there is no scientific basis. The purpose of this article is to address a new misinformed antivaccination argument—that measles immunity is undesirable because measles virus is protective against cancer. Having worked for many years to develop engineered measles viruses as anticancer therapies, we have concluded (1) that measles is not protective against cancer and (2) that its potential utility as a cancer therapy will be enhanced, not diminished, by prior vaccination.
Item Description:Gesehen am 07.04.2020
Physical Description:Online Resource
ISSN:1942-5546
DOI:10.1016/j.mayocp.2019.05.006

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