Transferrin receptor 2 controls bone mass and pathological bone formation via BMP and Wnt signalling
Transferrin receptor 2 (Trf2) is known to regulate iron homeostasis through its action in the liver. Here the authors report a previously unrecognised role of Trf2 in regulating bone homeostasis mediated by modulation of BMP signalling specifically on osteoblasts.
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
07 January 2019
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| In: |
Nature metabolism
Year: 2019, Volume: 1, Issue: 1, Pages: 111-124 |
| ISSN: | 2522-5812 |
| DOI: | 10.1038/s42255-018-0005-8 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s42255-018-0005-8 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s42255-018-0005-8 
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| Author Notes: | Martina Rauner, Ulrike Baschant, Antonella Roetto, Rosa Maria Pellegrino, Sandra Rother, Juliane Salbach-Hirsch, Heike Weidner, Vera Hintze, Graeme Campbell, Andreas Petzold, Regis Lemaitre, Ian Henry, Teresita Bellido, Igor Theurl, Sandro Altamura, Silvia Colucci, Martina U. Muckenthaler, Georg Schett, Davide S.K. Komla-Ebri, J.H. Duncan Bassett, Graham R. Williams, Uwe Platzbecker & Lorenz C. Hofbauer |
| Summary: | Transferrin receptor 2 (Trf2) is known to regulate iron homeostasis through its action in the liver. Here the authors report a previously unrecognised role of Trf2 in regulating bone homeostasis mediated by modulation of BMP signalling specifically on osteoblasts. |
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| Item Description: | Gesehen am 07.04.2020 |
| Physical Description: | Online Resource |
| ISSN: | 2522-5812 |
| DOI: | 10.1038/s42255-018-0005-8 |