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Circulating 27-hydroxycholesterol and breast cancer tissue expression of CYP27A1, CYP7B1, LXR-β, and ERβ: results from the EPIC-Heidelberg cohort

Experimental and epidemiological studies demonstrate a role for 27-hydroxycholesterol (27HC) in breast cancer development, though results are conflicting. Cholesterol 27-hydroxylase (CYP27A1) and oxysterol 7-alpha-hydroxylase (CYP7B1) regulate 27HC concentrations, while differential expression of th...

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Autori principali: Le Cornet, Charlotte (Autore) , Walter, Britta (Autore) , Sookthai, Disorn (Autore) , Johnson, Theron S. (Autore) , Kühn, Tilman (Autore) , Herpel, Esther (Autore) , Kaaks, Rudolf (Autore) , Turzanski Fortner, Renée (Autore)
Natura: Article (Journal)
Lingua:inglese
Pubblicazione: 19 February 2020
In: Breast cancer research
Year: 2020, Volume: 22, Pages: 1-10
ISSN:1465-542X
DOI:10.1186/s13058-020-1253-6
Accesso online:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13058-020-1253-6
Testo
Note sull'autore:Charlotte Le Cornet, Britta Walter, Disorn Sookthai, Theron S. Johnson, Tilman Kühn, Ester Herpel, Rudolf Kaaks and Renée T. Fortner
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Riassunto:Experimental and epidemiological studies demonstrate a role for 27-hydroxycholesterol (27HC) in breast cancer development, though results are conflicting. Cholesterol 27-hydroxylase (CYP27A1) and oxysterol 7-alpha-hydroxylase (CYP7B1) regulate 27HC concentrations, while differential expression of the liver X receptor (LXR) and estrogen receptor beta (ERβ) may impact the association between 27HC and breast cancer risk.
Descrizione del documento:Gesehen am 08.04.2020
Descrizione fisica:Online Resource
ISSN:1465-542X
DOI:10.1186/s13058-020-1253-6

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