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Circulating 27-hydroxycholesterol and breast cancer tissue expression of CYP27A1, CYP7B1, LXR-β, and ERβ: results from the EPIC-Heidelberg cohort

Experimental and epidemiological studies demonstrate a role for 27-hydroxycholesterol (27HC) in breast cancer development, though results are conflicting. Cholesterol 27-hydroxylase (CYP27A1) and oxysterol 7-alpha-hydroxylase (CYP7B1) regulate 27HC concentrations, while differential expression of th...

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Main Authors: Le Cornet, Charlotte (Author) , Walter, Britta (Author) , Sookthai, Disorn (Author) , Johnson, Theron S. (Author) , Kühn, Tilman (Author) , Herpel, Esther (Author) , Kaaks, Rudolf (Author) , Turzanski Fortner, Renée (Author)
Format: Article (Journal)
Language:English
Published: 19 February 2020
In: Breast cancer research
Year: 2020, Volume: 22, Pages: 1-10
ISSN:1465-542X
DOI:10.1186/s13058-020-1253-6
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13058-020-1253-6
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Author Notes:Charlotte Le Cornet, Britta Walter, Disorn Sookthai, Theron S. Johnson, Tilman Kühn, Ester Herpel, Rudolf Kaaks and Renée T. Fortner
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Summary:Experimental and epidemiological studies demonstrate a role for 27-hydroxycholesterol (27HC) in breast cancer development, though results are conflicting. Cholesterol 27-hydroxylase (CYP27A1) and oxysterol 7-alpha-hydroxylase (CYP7B1) regulate 27HC concentrations, while differential expression of the liver X receptor (LXR) and estrogen receptor beta (ERβ) may impact the association between 27HC and breast cancer risk.
Item Description:Gesehen am 08.04.2020
Physical Description:Online Resource
ISSN:1465-542X
DOI:10.1186/s13058-020-1253-6

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