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Endothelial Notch signaling controls insulin transport in muscle

The role of the endothelium is not just limited to acting as an inert barrier for facilitating blood transport. Endothelial cells (ECs), through expression of a repertoire of angiocrine molecules, regulate metabolic demands in an organ-specific manner. Insulin flux across the endothelium to muscle c...

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Main Authors: Safatul Hasan, Sana (Author) , Jabs, Markus (Author) , Taylor, Jacqueline (Author) , Wiedmann, Lena (Author) , Leibing, Thomas (Author) , Nordström, Viola (Author) , Federico, Giuseppina (Author) , Roma, Leticia P (Author) , Carlein, Christopher (Author) , Wolff, Gretchen (Author) , Ekim-Üstünel, Bilgen (Author) , Brune, Maik (Author) , Moll, Iris (Author) , Tetzlaff, Fabian (Author) , Gröne, Hermann-Josef (Author) , Fleming, Thomas (Author) , Géraud, Cyrill (Author) , Herzig, Stephan (Author) , Nawroth, Peter Paul (Author) , Fischer, Andreas (Author)
Format: Article (Journal)
Language:English
Published: 18 March 2020
In: EMBO molecular medicine
Year: 2020, Volume: 12, Issue: 4
ISSN:1757-4684
DOI:10.15252/emmm.201809271
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.15252/emmm.201809271
Verlag, lizenzpflichtig, Volltext: https://www.embopress.org/doi/full/10.15252/emmm.201809271
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Author Notes:Sana S Hasan, Markus Jabs, Jacqueline Taylor, Lena Wiedmann, Thomas Leibing, Viola Nordström, Giuseppina Federico, Leticia P Roma, Christopher Carlein, Gretchen Wolff, Bilgen Ekim-Üstünel, Maik Brune, Iris Moll, Fabian Tetzlaff, Hermann-Josef Gröne, Thomas Fleming, Cyrill Géraud, Stephan Herzig, Peter P Nawroth & Andreas Fischer
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Summary:The role of the endothelium is not just limited to acting as an inert barrier for facilitating blood transport. Endothelial cells (ECs), through expression of a repertoire of angiocrine molecules, regulate metabolic demands in an organ-specific manner. Insulin flux across the endothelium to muscle cells is a rate-limiting process influencing insulin-mediated lowering of blood glucose. Here, we demonstrate that Notch signaling in ECs regulates insulin transport to muscle.
Item Description:Gesehen am 08.04.2020
Physical Description:Online Resource
ISSN:1757-4684
DOI:10.15252/emmm.201809271

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