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Targeting phosphodiesterase-5 by vardenafil improves vascular graft function

Ischaemia reperfusion (IR) injury occurs during vascular graft harvesting and implantation during vascular/cardiac surgery. Elevated intracellular cyclic guanosine monophosphate (cGMP) levels contribute to an effective endothelial protection in different pathophysiological conditions. The hypothesis...

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Bibliographic Details
Main Authors: Veres, Gábor (Author) , Hagenhoff, Meike (Author) , Schmidt, Harald (Author) , Radovits, Tamás (Author) , Loganathan, Sivakkanan (Author) , Bai, Yang (Author) , Korkmaz-İçöz, Sevil (Author) , Brlecic, Paige (Author) , Sayour, Alex Ali (Author) , Karck, Matthias (Author) , Szabó, Gábor (Author)
Format: Article (Journal)
Language:English
Published: September 2018
In: European journal of vascular and endovascular surgery
Year: 2018, Volume: 56, Issue: 2, Pages: 256-263
ISSN:1532-2165
DOI:10.1016/j.ejvs.2018.03.025
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ejvs.2018.03.025
Verlag, lizenzpflichtig, Volltext: https://www.ejves.com/article/S1078-5884(18)30166-7/abstract
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Author Notes:Gábor Veres, Meike Hagenhoff, Harald Schmidt, Tamás Radovits, Sivakkanan Loganathan, Yang Bai, Sevil Korkmaz-Icöz, Paige Brlecic, Alex Ali Sayour, Matthias Karck, Gábor Szabó
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Summary:Ischaemia reperfusion (IR) injury occurs during vascular graft harvesting and implantation during vascular/cardiac surgery. Elevated intracellular cyclic guanosine monophosphate (cGMP) levels contribute to an effective endothelial protection in different pathophysiological conditions. The hypothesis that the phosphodiesterase-5 inhibitor vardenafil would protect vascular grafts against IR injury by upregulating the nitric oxide-cGMP pathway in the vessel wall of the bypass graft was investigated.
Item Description:Gesehen am 09.04.2020
Physical Description:Online Resource
ISSN:1532-2165
DOI:10.1016/j.ejvs.2018.03.025

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