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N-acetyl cysteine functions as a fast-acting antioxidant by triggering intracellular H2S and sulfane sulfur production

The cysteine prodrug N-acetyl cysteine (NAC) is widely used as a pharmacological antioxidant and cytoprotectant. It has been reported to lower endogenous oxidant levels and to protect cells against a wide range of pro-oxidative insults. As NAC itself is a poor scavenger of oxidants, the molecular me...

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Bibliographic Details
Main Authors: Ezeriņa, Daria (Author) , Takano, Yoko (Author) , Hanaoka, Kenjiro (Author) , Urano, Yasuteru (Author) , Dick, Tobias P. (Author)
Format: Article (Journal)
Language:English
Published: February 8, 2018
In: Cell chemical biology
Year: 2018, Volume: 25, Issue: 4, Pages: 447-459
ISSN:2451-9448
DOI:10.1016/j.chembiol.2018.01.011
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.chembiol.2018.01.011
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S2451945618300333
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Author Notes:Daria Ezeriņa, Yoko Takano, Kenjiro Hanaoka, Yasuteru Urano, and Tobias P. Dick
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Summary:The cysteine prodrug N-acetyl cysteine (NAC) is widely used as a pharmacological antioxidant and cytoprotectant. It has been reported to lower endogenous oxidant levels and to protect cells against a wide range of pro-oxidative insults. As NAC itself is a poor scavenger of oxidants, the molecular mechanisms behind the antioxidative effects of NAC have remained uncertain. Here we show that NAC-derived cysteine is desulfurated to generate hydrogen sulfide, which in turn is oxidized to sulfane sulfur species, predominantly within mitochondria. We provide evidence suggesting the possibility that sulfane sulfur species produced by 3-mercaptopyruvate sulfurtransferase and sulfide:quinone oxidoreductase are the actual mediators of the immediate antioxidative and cytoprotective effects provided by NAC.
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Physical Description:Online Resource
ISSN:2451-9448
DOI:10.1016/j.chembiol.2018.01.011

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