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Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin

Cutaneous squamous cell carcinoma (cSCC) is a skin cancer that normally progresses from UV-induced actinic keratosis (AK). Here, the authors investigate the epigenomics of cSCC and highlight two distinct subclasses of AK and cSCC originating from distinct keratinocyte differentiation stages.

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Bibliographic Details
Main Authors: Rodríguez Paredes, Manuel (Author) , Lucena Porcel, Carlota (Author) , Feuerbach, Lars (Author) , Brors, Benedikt (Author) , Herpel, Esther (Author) , Hofmann, Thomas G. (Author) , Lyko, Frank (Author)
Format: Article (Journal)
Language:English
Published: 08 February 2018
In: Nature Communications
Year: 2018, Volume: 9, Pages: 1-9
ISSN:2041-1723
DOI:10.1038/s41467-018-03025-1
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-018-03025-1
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-018-03025-1
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Author Notes:Manuel Rodríguez-Paredes, Felix Bormann, Günter Raddatz, Julian Gutekunst, Carlota Lucena-Porcel, Florian Köhler, Elisabeth Wurzer, Katrin Schmidt, Stefan Gallinat, Horst Wenck, Joachim Röwert-Huber, Evgeniya Denisova, Lars Feuerbach, Jeongbin Park, Benedikt Brors, Esther Herpel, Ingo Nindl, Thomas G. Hofmann, Marc Winnefeld & Frank Lyko
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Summary:Cutaneous squamous cell carcinoma (cSCC) is a skin cancer that normally progresses from UV-induced actinic keratosis (AK). Here, the authors investigate the epigenomics of cSCC and highlight two distinct subclasses of AK and cSCC originating from distinct keratinocyte differentiation stages.
Item Description:Gesehen am 14.04.2020
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-018-03025-1

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