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Unexpected excessive apixaban exposure: case report of a patient with polymorphisms of multiple apixaban elimination pathways

Apixaban effectively lowers the risk of ischemic stroke and systemic embolism in patients with non-valvular atrial fibrillation. Systemic exposure to a given apixaban dose depends on multiple clearance pathways. Though routine quantification of direct oral anticoagulants (DOACs) in neurological emer...

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Main Authors: Huppertz, Andrea (Author) , Grond-Ginsbach, Caspar (Author) , Dumschat, Chris (Author) , Foerster, Kathrin (Author) , Burhenne, Jürgen (Author) , Weiß, Johanna (Author) , Czock, David (Author) , Purrucker, Jan (Author) , Rizos, Timolaos (Author) , Haefeli, Walter E. (Author)
Format: Article (Journal)
Language:English
Published: 29 August 2019
In: BMC pharmacology & toxicology
Year: 2019, Volume: 20, Issue: 1
ISSN:2050-6511
DOI:10.1186/s40360-019-0331-9
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s40360-019-0331-9
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Author Notes:Andrea Huppertz, Caspar Grond-Ginsbach, Chris Dumschat, Kathrin I. Foerster, Jürgen Burhenne, Johanna Weiss, David Czock, Jan C. Purrucker, Timolaos Rizos, and Walter E. Haefeli
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Summary:Apixaban effectively lowers the risk of ischemic stroke and systemic embolism in patients with non-valvular atrial fibrillation. Systemic exposure to a given apixaban dose depends on multiple clearance pathways. Though routine quantification of direct oral anticoagulants (DOACs) in neurological emergency situations has not been widely established, suspected associations of DOAC peak concentrations with bleeding events and DOAC trough concentrations with efficacy and safety suggest that such information might support clinical decision making.
Item Description:Gesehen am 15.04.2020
Physical Description:Online Resource
ISSN:2050-6511
DOI:10.1186/s40360-019-0331-9

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