Idarucizumab for reversal of dabigatran in early/emergency surgeries: a case series
Background - Idarucizumab is a humanized, monoclonal antibody fragment used specifically to reverse the anticoagulant effects of dabigatran. - Case Reports - We discuss 4 cases of patients who were treated with idarucizumab to reverse dabigatran before early/emergency surgery. Two of the patients ha...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
December 2019
|
| In: |
The journal of emergency medicine
Year: 2019, Volume: 57, Issue: 6, Pages: e167-e173 |
| ISSN: | 0736-4679 |
| DOI: | 10.1016/j.jemermed.2019.09.038 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.jemermed.2019.09.038 Verlag, kostenfrei, Volltext: http://www.sciencedirect.com/science/article/pii/S0736467919308212 
|
| Author Notes: | W. Frank Peacock, James C. Grotta, Thorsten Steiner |
| Summary: | Background - Idarucizumab is a humanized, monoclonal antibody fragment used specifically to reverse the anticoagulant effects of dabigatran. - Case Reports - We discuss 4 cases of patients who were treated with idarucizumab to reverse dabigatran before early/emergency surgery. Two of the patients had subdural hematomas, 1 had a splenic laceration, and 1 had Fournier gangrene. All patients received 5 g of idarucizumab before surgery. Intraoperative blood loss in all patients was normal, no adverse events were reported, and the patients recovered normally. - Why Should an Emergency Physician be Aware of This? - The case reports presented provide detailed, practical, real-world experience beyond that reported in other case reports and the Reversal Effects of Idarucizumab on Active Dabigatran study. This can help guide clinicians on how idarucizumab can reverse the anticoagulant effect of dabigatran in emergency situations, including patients with subdural hematoma. Our experience suggests that idarucizumab may be a safe and effective antidote to the effects of dabigatran in real-life bleeding situations involving early or emergency surgeries. |
|---|---|
| Item Description: | Gesehen am 15.04.2020 |
| Physical Description: | Online Resource |
| ISSN: | 0736-4679 |
| DOI: | 10.1016/j.jemermed.2019.09.038 |