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Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis

Background - Little is known about the role of interleukin (IL)-1 in the pathogenesis of cystic fibrosis (CF) lung disease. This study investigated the relationship between IL-1 signalling, neutrophilic inflammation and structural lung changes in children with CF. - Methods - Bronchoalveolar lavage...

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Bibliographic Details
Main Authors: Montgomery, Samuel T. (Author) , Dittrich, A. Susanne (Author) , Frey, Dario (Author) , Mall, Marcus A. (Author)
Format: Article (Journal)
Language:English
Published: 6 June 2018
In: Journal of cystic fibrosis
Year: 2018, Volume: 17, Issue: 6, Pages: 715-722
ISSN:1873-5010
DOI:10.1016/j.jcf.2018.05.006
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jcf.2018.05.006
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S1569199318305885
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Author Notes:Samuel T. Montgomery, A. Susanne Dittrich, Luke W. Garratt, Lidija Turkovic, Dario L. Frey, Stephen M. Stick, Marcus A. Mall, Anthony Kicic
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Summary:Background - Little is known about the role of interleukin (IL)-1 in the pathogenesis of cystic fibrosis (CF) lung disease. This study investigated the relationship between IL-1 signalling, neutrophilic inflammation and structural lung changes in children with CF. - Methods - Bronchoalveolar lavage fluid (BALf) from 102 children with CF were used to determine IL-1α, IL-1β, IL-8 levels and neutrophil elastase (NE) activity, which were then correlated to structural lung changes observed on chest computed tomography (CT) scans. - Results - IL-1α and IL-1β were detectable in BAL in absence of infection, increased in the presence of bacterial infection and correlated with IL-8 (p<0.0001), neutrophils (p<0.0001) and NE activity (p<0.01 and p<0.001). IL-1α had the strongest association with structural lung disease (p <0.01) in the absence of infection (uninfected: p<0.01 vs. infected: p=0.122). - Conclusion - Our data associates IL-1α with early structural lung damage in CF and suggests this pathway as a novel anti-inflammatory target.
Item Description:Gesehen am 16.04.2020
Physical Description:Online Resource
ISSN:1873-5010
DOI:10.1016/j.jcf.2018.05.006

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