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Correlation of ki-67 index with volumetric segmentation and its value as a prognostic marker in glioblastoma

Objective - Previous research has shown a strong correlation between the Ki-67 proliferation index and grade of malignancy in astrocytoma. Ki-67 has also shown encouraging results as a prognostic marker for patients' overall survival (OS). We focus on whether the index is linked to the appearan...

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Hauptverfasser: Henker, Christian (VerfasserIn) , Kriesen, Thomas (VerfasserIn) , Schneider, Björn (VerfasserIn) , Glass, Änne (VerfasserIn) , Scherer, Moritz (VerfasserIn) , Langner, Sönke (VerfasserIn) , Erbersdobler, Andreas (VerfasserIn) , Piek, Jürgen (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: May 2019
In: World neurosurgery
Year: 2019, Jahrgang: 125, Pages: e1093-e1103
ISSN:1878-8769
DOI:10.1016/j.wneu.2019.02.006
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.wneu.2019.02.006
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S1878875019303699
Volltext
Verfasserangaben:Christian Henker, Thomas Kriesen, Björn Schneider, Änne Glass, Moritz Scherer, Sönke Langner, Andreas Erbersdobler, Jürgen Piek
Beschreibung
Zusammenfassung:Objective - Previous research has shown a strong correlation between the Ki-67 proliferation index and grade of malignancy in astrocytoma. Ki-67 has also shown encouraging results as a prognostic marker for patients' overall survival (OS). We focus on whether the index is linked to the appearance of glioblastoma on pretreatment magnetic resonance imaging (MRI) or to OS. - Methods - In our retrospective study, only isocitrate dehydrogenase IDH wild-type glioblastoma was included (n = 152). Ki-67 index was quantified via immunohistochemistry. On all pretreatment MRI, tumor compartments (tumor, necrosis, and edema) were volumetrically assessed. An OS subpopulation was filtered from the total cohort (residual tumor volume ≤2 cm3). In addition, a propensity score matching was executed. - Results - All volumetric assessed tumor volumes correlated with each other (P ≤ 0.011), although the Ki-67 index showed no correlation with any of the measured volumes. Concerning the OS, a cutoff value of 20% for the Ki-67 index showed a significant influence on patients' OS in multivariate analysis (P = 0.043). - Conclusions - The unique appearance of every glioblastoma on MRI seems to be independent of the Ki-67 index. Furthermore, the Ki-67 index did show a distinct prognostic value for OS within our cohort at a cutoff value of 20% for Ki-67.
Beschreibung:Gesehen am 16.04.2020
Beschreibung:Online Resource
ISSN:1878-8769
DOI:10.1016/j.wneu.2019.02.006

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