Correlation of ki-67 index with volumetric segmentation and its value as a prognostic marker in glioblastoma
Objective - Previous research has shown a strong correlation between the Ki-67 proliferation index and grade of malignancy in astrocytoma. Ki-67 has also shown encouraging results as a prognostic marker for patients' overall survival (OS). We focus on whether the index is linked to the appearan...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
May 2019
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| In: |
World neurosurgery
Year: 2019, Jahrgang: 125, Pages: e1093-e1103 |
| ISSN: | 1878-8769 |
| DOI: | 10.1016/j.wneu.2019.02.006 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.wneu.2019.02.006 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S1878875019303699 
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| Verfasserangaben: | Christian Henker, Thomas Kriesen, Björn Schneider, Änne Glass, Moritz Scherer, Sönke Langner, Andreas Erbersdobler, Jürgen Piek |
MARC
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| 245 | 1 | 0 | |a Correlation of ki-67 index with volumetric segmentation and its value as a prognostic marker in glioblastoma |c Christian Henker, Thomas Kriesen, Björn Schneider, Änne Glass, Moritz Scherer, Sönke Langner, Andreas Erbersdobler, Jürgen Piek |
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| 520 | |a Objective - Previous research has shown a strong correlation between the Ki-67 proliferation index and grade of malignancy in astrocytoma. Ki-67 has also shown encouraging results as a prognostic marker for patients' overall survival (OS). We focus on whether the index is linked to the appearance of glioblastoma on pretreatment magnetic resonance imaging (MRI) or to OS. - Methods - In our retrospective study, only isocitrate dehydrogenase IDH wild-type glioblastoma was included (n = 152). Ki-67 index was quantified via immunohistochemistry. On all pretreatment MRI, tumor compartments (tumor, necrosis, and edema) were volumetrically assessed. An OS subpopulation was filtered from the total cohort (residual tumor volume ≤2 cm3). In addition, a propensity score matching was executed. - Results - All volumetric assessed tumor volumes correlated with each other (P ≤ 0.011), although the Ki-67 index showed no correlation with any of the measured volumes. Concerning the OS, a cutoff value of 20% for the Ki-67 index showed a significant influence on patients' OS in multivariate analysis (P = 0.043). - Conclusions - The unique appearance of every glioblastoma on MRI seems to be independent of the Ki-67 index. Furthermore, the Ki-67 index did show a distinct prognostic value for OS within our cohort at a cutoff value of 20% for Ki-67. | ||
| 650 | 4 | |a Glioblastoma | |
| 650 | 4 | |a Ki-67 | |
| 650 | 4 | |a Magnetic resonance imaging | |
| 650 | 4 | |a Neuroimaging | |
| 650 | 4 | |a Prognosis | |
| 650 | 4 | |a Prognostic marker | |
| 650 | 4 | |a Segmentation | |
| 700 | 1 | |a Kriesen, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schneider, Björn |e VerfasserIn |4 aut | |
| 700 | 1 | |a Glass, Änne |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Langner, Sönke |e VerfasserIn |4 aut | |
| 700 | 1 | |a Erbersdobler, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Piek, Jürgen |e VerfasserIn |4 aut | |
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