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Validation of inflammatory genetic variants associated with long-term cancer related fatigue in a large breast cancer cohort

Studies to date have reported several associations between single nucleotide polymorphisms (SNPs) and cancer related fatigue (CRF), but have been limited by small sample sizes, missing adjustment for relevant covariates or multiple testing, as well as varying CRF definitions, i.e. time and method of...

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Main Authors: Maurer, Tabea (Author) , Behrens, S. (Author) , Jung, A. Y. (Author) , Obi, N. (Author) , Thöne, K. (Author) , Schmidt, Martina (Author) , Becher, Heiko (Author) , Chang-Claude, Jenny (Author)
Format: Article (Journal)
Language:English
Published: 18 May 2018
In: Brain, behavior and immunity
Year: 2018, Volume: 73, Pages: 252-260
ISSN:1090-2139
DOI:10.1016/j.bbi.2018.05.009
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.bbi.2018.05.009
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0889159118301806
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Author Notes:T. Kühl, S. Behrens, A.Y. Jung, N. Obi, K. Thöne, M.E. Schmidt, H. Becher, J. Chang-Claude
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Summary:Studies to date have reported several associations between single nucleotide polymorphisms (SNPs) and cancer related fatigue (CRF), but have been limited by small sample sizes, missing adjustment for relevant covariates or multiple testing, as well as varying CRF definitions, i.e. time and method of assessment. This study aimed to validate previously reported associations using the largest independent breast cancer sample to date and to evaluate further functional cytokine variants in relation to total CRF and all relevant CRF subdomains (physical, cognitive, and affective CRF).
Item Description:Gesehen am 16.04.2020
Physical Description:Online Resource
ISSN:1090-2139
DOI:10.1016/j.bbi.2018.05.009

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