Tuberculosis test results using fresh versus biobanked urine samples with FujiLAM
We agree with John T Connelly and colleagues1 that assessment of analyte stability - and matrix effects must be part of every assay validation. It is, however, essential - that validation is done with the assay under consideration, as different lipoarabinomannan - (LAM) assays use different reagents...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
January 01, 2020
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| In: |
The lancet. Infectious diseases
Year: 2020, Volume: 20, Issue: 1, Pages: 22-23 |
| ISSN: | 1474-4457 |
| DOI: | 10.1016/S1473-3099(19)30684-X |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/S1473-3099(19)30684-X Verlag, kostenfrei, Volltext: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(19)30684-X/abstract 
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| Author Notes: | Tobias Broger, Monde Muyoyeta, Andrew D. Kerkhoff, Claudia M. Denkinger, Emmanuel Moreau |
| Summary: | We agree with John T Connelly and colleagues1 that assessment of analyte stability - and matrix effects must be part of every assay validation. It is, however, essential - that validation is done with the assay under consideration, as different lipoarabinomannan - (LAM) assays use different reagents that bind to different LAM epitopes with different - stabilities or availabilities. Therefore, results from the research assay described - by Connelly and colleagues,1 showing rapid signal loss, are not generalisable to other - LAM tests. |
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| Item Description: | Gesehen am 17.04.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1474-4457 |
| DOI: | 10.1016/S1473-3099(19)30684-X |