Cover Image

Phenotypic multiorgan involvement of subclinical disease as quantified by magnetic resonance imaging in subjects with prediabetes, diabetes, and normal glucose tolerance

Introduction: Detailed mechanisms in the pathophysiology of diabetes disease are poorly understood, but structural alterations in various organ systems incur an elevated risk for cardiovascular events and adverse outcome. The aim of this study was to compare multiorgan subclinical disease phenotypes...

Full description

Saved in:
Bibliographic Details
Main Authors: Storz, Corinna (Author) , Rospleszcz, Susanne (Author) , Lorbeer, Roberto (Author) , Hetterich, Holger (Author) , Auweter, Sigrid D. (Author) , Sommer, Wieland (Author) , Machann, Jürgen (Author) , Gatidis, Sergios (Author) , Rathmann, Wolfgang (Author) , Heier, Margit (Author) , Linkohr, Birgit (Author) , Meisinger, Christa (Author) , Reiser, Maximilian (Author) , Hoffmann, Udo (Author) , Peters, Annette (Author) , Schlett, Christopher L. (Author) , Bamberg, Fabian (Author)
Format: Article (Journal)
Language:English
Published: 2018
In: Investigative radiology
Year: 2018, Volume: 53, Issue: 6, Pages: 357-364
ISSN:1536-0210
DOI:10.1097/RLI.0000000000000451
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/RLI.0000000000000451
Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/investigativeradiology/Abstract/2018/06000/Phenotypic_Multiorgan_Involvement_of_Subclinical.6.aspx
Get full text
Author Notes:Corinna Storz, Susanne Rospleszcz, Roberto Lorbeer, Holger Hetterich, Sigrid D. Auweter, Wieland Sommer, Jürgen Machann, Sergios Gatidis, Wolfgang Rathmann, Margit Heier, Birgit Linkohr, Christa Meisinger, Maximilian Reiser, Udo Hoffmann, Annette Peters, Christopher L. Schlett, Fabian Bamberg
Description
Summary:Introduction: Detailed mechanisms in the pathophysiology of diabetes disease are poorly understood, but structural alterations in various organ systems incur an elevated risk for cardiovascular events and adverse outcome. The aim of this study was to compare multiorgan subclinical disease phenotypes by magnetic resonance (MR) imaging to study differences between subjects with prediabetes, diabetes, and normal controls. Materials and Methods: Subjects without prior cardiovascular disease were enrolled in a prospective case-control study and underwent multiorgan MR for the assessment of metabolic and arteriosclerotic alterations, including age-related white matter changes, hepatic proton density fat fraction, visceral adipose tissue volume, left ventricular remodeling index, carotid plaque, and late gadolinium enhancement. Magnetic resonance features were summarized in a phenotypic-based score (range, 0-6). Univariate, multivariate correlation, and unsupervised clustering were performed. Results: Among 243 subjects with complete multiorgan MR data sets included in the analysis (55.6 ± 8.9 years, 62% males), 48 were classified as subjects with prediabetes and 38 as subjects with diabetes. The MR phenotypic score was significantly higher in subjects with prediabetes and diabetes as compared with controls (mean score, 3.00 ± 1.04 and 2.69 ± 0.98 vs 1.22 ± 0.98, P < 0.001 respectively), also after adjustment for potential confounders. We identified 2 clusters of MR phenotype patterns associated with glycemic status (P < 0.001), independent of the MR score (cluster II-metabolic specific: odds ratio, 2.49; 95% CI, 1.00-6.17; P = 0.049). Discussion: Subjects with prediabetes and diabetes have a significantly higher phenotypic-based score with a distinctive multiorgan phenotypic pattern, which may enable improved disease characterization.
Item Description:Gesehen am 20.04.2020
Physical Description:Online Resource
ISSN:1536-0210
DOI:10.1097/RLI.0000000000000451

Similar Items