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M2 macrophage marker chitinase 3-like 2 (CHI3L2) associates with progression of conventional renal cell carcinoma

Background/Aim: In spite of early detection, appoximately 15% of the small renal cell carcinomas (RCC) will develop metastasis within 5 years follow-up. The aim of this study was to identify new biomarkers to estimate the postoperative relapse of the most common conventional RCC. Patients and Method...

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Main Authors: Pusztai, Csaba (Author) , Yusenko, Maria V. (Author) , Banyai, Daniel (Author) , Szanto, Arpad (Author) , Kovacs, Gyula (Author)
Format: Article (Journal)
Language:English
Published: [December 2019]
In: Anticancer research
Year: 2019, Volume: 39, Issue: 12, Pages: 6939-6943
ISSN:1791-7530
DOI:10.21873/anticanres.13915
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.21873/anticanres.13915
Verlag, lizenzpflichtig, Volltext: http://ar.iiarjournals.org/content/39/12/6939
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Author Notes:Csaba Pusztai, Maria V. Yusenko, Daniel Banyai, Arpad Szanto, and Gyula Kovacs
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Summary:Background/Aim: In spite of early detection, appoximately 15% of the small renal cell carcinomas (RCC) will develop metastasis within 5 years follow-up. The aim of this study was to identify new biomarkers to estimate the postoperative relapse of the most common conventional RCC. Patients and Methods: Tissue multi arrays of conventional RCC without metastasis at the time of operation from a cohort of 634 patients were analysed by immunohistochemistry for expression of the chitinase 3-like protein 2 (CHI3L2). Cancer specific survival of patients was estimated with Kaplan-Meier analysis, univariate and multivariate Cox regression models. Results: Kaplan-Meier analysis estimated a shorter cancer-free survival for patients with CHI3L2 positive tumors. In multivariate analysis, the CHI3L2 positivity associated with a 3.5 times higher risk for tumor relapse (p<0.001). Conclusion: Expression of CHI3L2 in tumor cells of conventional RCC define a group of patients at high risk for postoperative progression.
Item Description:Gesehen am 20.04.2020
Physical Description:Online Resource
ISSN:1791-7530
DOI:10.21873/anticanres.13915

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