Buchumschlag

M2 macrophage marker chitinase 3-like 2 (CHI3L2) associates with progression of conventional renal cell carcinoma

Background/Aim: In spite of early detection, appoximately 15% of the small renal cell carcinomas (RCC) will develop metastasis within 5 years follow-up. The aim of this study was to identify new biomarkers to estimate the postoperative relapse of the most common conventional RCC. Patients and Method...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Pusztai, Csaba (VerfasserIn) , Yusenko, Maria V. (VerfasserIn) , Banyai, Daniel (VerfasserIn) , Szanto, Arpad (VerfasserIn) , Kovacs, Gyula (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: [December 2019]
In: Anticancer research
Year: 2019, Jahrgang: 39, Heft: 12, Pages: 6939-6943
ISSN:1791-7530
DOI:10.21873/anticanres.13915
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.21873/anticanres.13915
Verlag, lizenzpflichtig, Volltext: http://ar.iiarjournals.org/content/39/12/6939
Volltext
Verfasserangaben:Csaba Pusztai, Maria V. Yusenko, Daniel Banyai, Arpad Szanto, and Gyula Kovacs
Beschreibung
Zusammenfassung:Background/Aim: In spite of early detection, appoximately 15% of the small renal cell carcinomas (RCC) will develop metastasis within 5 years follow-up. The aim of this study was to identify new biomarkers to estimate the postoperative relapse of the most common conventional RCC. Patients and Methods: Tissue multi arrays of conventional RCC without metastasis at the time of operation from a cohort of 634 patients were analysed by immunohistochemistry for expression of the chitinase 3-like protein 2 (CHI3L2). Cancer specific survival of patients was estimated with Kaplan-Meier analysis, univariate and multivariate Cox regression models. Results: Kaplan-Meier analysis estimated a shorter cancer-free survival for patients with CHI3L2 positive tumors. In multivariate analysis, the CHI3L2 positivity associated with a 3.5 times higher risk for tumor relapse (p<0.001). Conclusion: Expression of CHI3L2 in tumor cells of conventional RCC define a group of patients at high risk for postoperative progression.
Beschreibung:Gesehen am 20.04.2020
Beschreibung:Online Resource
ISSN:1791-7530
DOI:10.21873/anticanres.13915

Ähnliche Einträge