Cover Image

Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs

How cancer cells engage the microenvironment to establish metastasis is poorly understood. Here, the authors show that CXCR3-expressing breast cancer cells secrete IL-1 to induce a paracrine crosstalk with fibroblasts in the lung, which involves CXCL9/10 production and results in colonization of the...

Full description

Saved in:
Bibliographic Details
Main Authors: Pein, Maren (Author) , Insua-Rodríguez, Jacob (Author) , Hongu, Tsunaki (Author) , Riedel, Angela (Author) , Meier, Jasmin (Author) , Wiedmann, Lena (Author) , Decker, Kristin (Author) , Essers, Marieke (Author) , Sinn, Peter (Author) , Spaich, Saskia (Author) , Sütterlin, Marc (Author) , Schneeweiss, Andreas (Author) , Trumpp, Andreas (Author) , Oskarsson, Thordur (Author)
Format: Article (Journal)
Language:English
Published: [2020]
In: Nature Communications
Year: 2020, Volume: 11
ISSN:2041-1723
DOI:10.1038/s41467-020-15188-x
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-020-15188-x
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-020-15188-x
Get full text
Author Notes:Maren Pein, Jacob Insua-Rodríguez, Tsunaki Hongu, Angela Riedel, Jasmin Meier, Lena Wiedmann, Kristin Decker, Marieke A. G. Essers, Hans-Peter Sinn, Saskia Spaich, Marc Sütterlin, Andreas Schneeweiss, Andreas Trumpp, Thordur Oskarsson
Description
Summary:How cancer cells engage the microenvironment to establish metastasis is poorly understood. Here, the authors show that CXCR3-expressing breast cancer cells secrete IL-1 to induce a paracrine crosstalk with fibroblasts in the lung, which involves CXCL9/10 production and results in colonization of the lung.
Item Description:Gesehen am 21.04.2020
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-020-15188-x

Similar Items