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OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation

The re-wiring of the metabolic machinery is a common feature in cancer. Here, the authors show, using paired normal and prostate cancer samples that the cancer samples exhibit a shift to succinate respiration, which is associated with elevated levels of mitochondrial DNA mutations.

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Bibliographic Details
Main Authors: Schöpf, Bernd (Author) , Weissensteiner, Hansi (Author) , Schäfer, Georg (Author) , Fazzini, Federica (Author) , Charoentong, Pornpimol (Author) , Naschberger, Andreas (Author) , Rupp, Bernhard (Author) , Fendt, Liane (Author) , Bukur, Valesca (Author) , Giese, Irina (Author) , Sorn, Patrick (Author) , Sant’Anna-Silva, Ana Carolina (Author) , Iglesias-Gonzalez, Javier (Author) , Sahin, Ugur (Author) , Kronenberg, Florian (Author) , Gnaiger, Erich (Author) , Klocker, Helmut (Author)
Format: Article (Journal)
Language:English
Published: [2020]
In: Nature Communications
Year: 2020, Volume: 11
ISSN:2041-1723
DOI:10.1038/s41467-020-15237-5
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-020-15237-5
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-020-15237-5
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Author Notes:Bernd Schöpf, Hansi Weissensteiner, Georg Schäfer, Federica Fazzini, Pornpimol Charoentong, Andreas Naschberger, Bernhard Rupp, Liane Fendt, Valesca Bukur, Irina Giese, Patrick Sorn, Ana Carolina Sant’Anna-Silva, Javier Iglesias-Gonzalez, Ugur Sahin, Florian Kronenberg, Erich Gnaiger & Helmut Klocker
Description
Summary:The re-wiring of the metabolic machinery is a common feature in cancer. Here, the authors show, using paired normal and prostate cancer samples that the cancer samples exhibit a shift to succinate respiration, which is associated with elevated levels of mitochondrial DNA mutations.
Item Description:Gesehen am 21.04.2020
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-020-15237-5

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